Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prcAT/RES-TIGR02293
Location 5217651..5218534 Replicon chromosome
Accession NZ_CP123953
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name PrcT Uniprot ID -
Locus tag P4N66_RS24920 Protein ID WP_231980891.1
Coordinates 5217651..5218031 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name PrcA Uniprot ID S6AKX1
Locus tag P4N66_RS24925 Protein ID WP_011078033.1
Coordinates 5218085..5218534 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS24895 (P4N66_gene4946) 5213127..5213345 - 219 WP_254176716.1 endonuclease -
P4N66_RS24900 (P4N66_gene4947) 5213435..5214832 - 1398 WP_047296850.1 hypothetical protein -
P4N66_RS24905 (P4N66_gene4948) 5214832..5215950 - 1119 WP_011600754.1 toxic anion resistance protein -
P4N66_RS24910 (P4N66_gene4949) 5215961..5216734 - 774 WP_011600753.1 tellurite resistance protein -
P4N66_RS24915 (P4N66_gene4950) 5216940..5217299 - 360 WP_016502323.1 hypothetical protein -
P4N66_RS24920 5217651..5218031 - 381 WP_231980891.1 RES family NAD+ phosphorylase Toxin
P4N66_RS24925 (P4N66_gene4951) 5218085..5218534 - 450 WP_011078033.1 DUF2384 domain-containing protein Antitoxin
P4N66_RS24930 (P4N66_gene4952) 5218950..5219273 - 324 WP_047296954.1 hypothetical protein -
P4N66_RS24935 (P4N66_gene4953) 5219306..5219560 - 255 WP_047296953.1 hypothetical protein -
P4N66_RS24940 5219577..5219813 - 237 WP_047296951.1 hypothetical protein -
P4N66_RS24945 (P4N66_gene4955) 5219825..5220259 - 435 WP_047296950.1 hypothetical protein -
P4N66_RS24950 (P4N66_gene4956) 5220353..5221597 - 1245 WP_172691824.1 DUF1173 family protein -
P4N66_RS24955 (P4N66_gene4957) 5221621..5222391 - 771 WP_222236178.1 hypothetical protein -
P4N66_RS24960 (P4N66_gene4958) 5222837..5223283 + 447 Protein_4942 pyridoxal-phosphate dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul1 / catB3 / blaOXA-1 / blaIMP-45 / mph(A) / aac(3)-IId - 5123644..5591374 467730


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-115)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(97-146)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13820.73 Da        Isoelectric Point: 4.3068

>T279251 WP_231980891.1 NZ_CP123953:c5218031-5217651 [Pseudomonas aeruginosa]
VSGRWHQAGRPVVYTATSPPGAMLEVLVHLEIDPEDFPATMQLLRIEVPDSVSQAQMPTLPAGWSAETELTRGIGNQFLD
ECNALLLPVPSAIIPSTVNYLFNPRHPEAQSATIQVELFTPDSRLF

Download         Length: 381 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16963.45 Da        Isoelectric Point: 6.1074

>AT279251 WP_011078033.1 NZ_CP123953:c5218534-5218085 [Pseudomonas aeruginosa]
MLAEVLRDHGYSAYRARLQILLEIPESASDFEIHTRISHGFSAARLMRLTEEGVVTPLERDQIIPLRTLKNRIERDQPLT
VEESDRLFRSAHITAMAEAIFGDADKAKRWLSKPKERFSGLTPMQLLTTQQGTSQVEEMLLQIAEGFAL

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S6AKX1

References