Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3885304..3886525 Replicon chromosome
Accession NZ_CP123953
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag P4N66_RS18865 Protein ID WP_003102740.1
Coordinates 3885304..3885882 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P4N66_RS18870 Protein ID WP_003088112.1
Coordinates 3885971..3886525 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS18850 (P4N66_gene3752) 3880580..3881857 + 1278 WP_003102743.1 TolC family protein -
P4N66_RS18855 (P4N66_gene3753) 3881847..3884018 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
P4N66_RS18860 (P4N66_gene3754) 3884008..3885195 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
P4N66_RS18865 (P4N66_gene3755) 3885304..3885882 - 579 WP_003102740.1 HD domain-containing protein Toxin
P4N66_RS18870 (P4N66_gene3756) 3885971..3886525 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P4N66_RS18875 (P4N66_gene3757) 3886683..3888878 - 2196 WP_058007015.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P4N66_RS18880 (P4N66_gene3758) 3888883..3889344 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
P4N66_RS18885 (P4N66_gene3759) 3889675..3889998 + 324 WP_003102734.1 multidrug efflux SMR transporter -
P4N66_RS18890 (P4N66_gene3760) 3890011..3890409 + 399 WP_023089053.1 NADH-quinone oxidoreductase subunit A -
P4N66_RS18895 (P4N66_gene3761) 3890406..3890957 - 552 WP_003450159.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T279250 WP_003102740.1 NZ_CP123953:c3885882-3885304 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT279250 WP_003088112.1 NZ_CP123953:c3886525-3885971 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References