Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2923540..2924798 Replicon chromosome
Accession NZ_CP123953
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag P4N66_RS14220 Protein ID WP_003163133.1
Coordinates 2924043..2924798 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag P4N66_RS14215 Protein ID WP_003086329.1
Coordinates 2923540..2923908 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS14195 2919703..2919978 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
P4N66_RS14200 (P4N66_gene2829) 2919981..2920457 - 477 WP_003112531.1 hypothetical protein -
P4N66_RS14205 (P4N66_gene2830) 2920632..2922125 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
P4N66_RS14210 (P4N66_gene2831) 2922181..2923467 + 1287 WP_003112529.1 FAD-binding oxidoreductase -
P4N66_RS14215 (P4N66_gene2832) 2923540..2923908 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
P4N66_RS14220 (P4N66_gene2833) 2924043..2924798 + 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
P4N66_RS14225 (P4N66_gene2834) 2925568..2926929 + 1362 WP_003081943.1 DNA recombination protein RmuC -
P4N66_RS14230 (P4N66_gene2835) 2927084..2929627 - 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T279249 WP_003163133.1 NZ_CP123953:2924043-2924798 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT279249 WP_003086329.1 NZ_CP123953:2923540-2923908 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References