Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2842124..2842710 Replicon chromosome
Accession NZ_CP123953
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag P4N66_RS13780 Protein ID WP_003120987.1
Coordinates 2842124..2842423 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag P4N66_RS13785 Protein ID WP_003448662.1
Coordinates 2842420..2842710 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS13760 (P4N66_gene2743) 2837237..2837770 - 534 WP_023094340.1 type IV pilus biogenesis protein PilP -
P4N66_RS13765 (P4N66_gene2744) 2837760..2839085 - 1326 WP_003099758.1 type 4b pilus protein PilO2 -
P4N66_RS13770 (P4N66_gene2745) 2839089..2840798 - 1710 WP_003123331.1 PilN family type IVB pilus formation outer membrane protein -
P4N66_RS13775 (P4N66_gene2746) 2840798..2841922 - 1125 WP_023082046.1 TcpQ domain-containing protein -
P4N66_RS13780 (P4N66_gene2747) 2842124..2842423 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P4N66_RS13785 (P4N66_gene2748) 2842420..2842710 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
P4N66_RS13790 (P4N66_gene2749) 2842781..2843125 - 345 WP_023082045.1 hypothetical protein -
P4N66_RS13795 (P4N66_gene2750) 2843264..2845240 - 1977 WP_031691363.1 DEAD/DEAH box helicase -
P4N66_RS13800 (P4N66_gene2751) 2845237..2847126 - 1890 WP_023101908.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2784022..2876777 92755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T279248 WP_003120987.1 NZ_CP123953:2842124-2842423 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT279248 WP_003448662.1 NZ_CP123953:2842420-2842710 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References