Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 625117..625754 Replicon chromosome
Accession NZ_CP123953
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P4N66_RS02940 Protein ID WP_019725766.1
Coordinates 625117..625299 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P4N66_RS02945 Protein ID WP_019725767.1
Coordinates 625332..625754 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS02920 622099..622242 + 144 WP_152959728.1 hypothetical protein -
P4N66_RS02925 (P4N66_gene0585) 622569..622868 - 300 WP_175597830.1 nuclease-related domain-containing protein -
P4N66_RS02930 (P4N66_gene0586) 622997..624118 - 1122 WP_003117952.1 Fic family protein -
P4N66_RS02935 624377..624514 - 138 WP_003113217.1 hypothetical protein -
P4N66_RS02940 (P4N66_gene0588) 625117..625299 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
P4N66_RS02945 (P4N66_gene0589) 625332..625754 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P4N66_RS02950 (P4N66_gene0591) 626000..626971 - 972 WP_025982283.1 hypothetical protein -
P4N66_RS02955 (P4N66_gene0592) 626956..627648 - 693 WP_019725770.1 hypothetical protein -
P4N66_RS02960 (P4N66_gene0593) 627645..628187 - 543 WP_025982284.1 hypothetical protein -
P4N66_RS02965 (P4N66_gene0594) 628184..629107 - 924 WP_019725772.1 hypothetical protein -
P4N66_RS02970 (P4N66_gene0595) 629104..629580 - 477 WP_019725773.1 phage tail assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 622997..676334 53337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T279246 WP_019725766.1 NZ_CP123953:625117-625299 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT279246 WP_019725767.1 NZ_CP123953:625332-625754 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References