Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143924..144429 Replicon chromosome
Accession NZ_CP123953
Organism Pseudomonas aeruginosa strain 59

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag P4N66_RS00670 Protein ID WP_003083773.1
Coordinates 143924..144205 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag P4N66_RS00675 Protein ID WP_003083775.1
Coordinates 144202..144429 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4N66_RS00645 (P4N66_gene0125) 139175..140524 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
P4N66_RS00650 (P4N66_gene0126) 140573..141259 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
P4N66_RS00655 (P4N66_gene0127) 141360..142094 + 735 WP_003101224.1 GntR family transcriptional regulator -
P4N66_RS00660 (P4N66_gene0128) 142274..142684 + 411 WP_003101225.1 aegerolysin family protein -
P4N66_RS00665 (P4N66_gene0129) 142716..143624 - 909 WP_003083769.1 LysR family transcriptional regulator -
P4N66_RS00670 (P4N66_gene0130) 143924..144205 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
P4N66_RS00675 (P4N66_gene0131) 144202..144429 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
P4N66_RS00680 (P4N66_gene0132) 144605..145225 - 621 WP_003101226.1 hypothetical protein -
P4N66_RS00685 (P4N66_gene0133) 145326..145826 + 501 WP_003101228.1 LEA type 2 family protein -
P4N66_RS00690 (P4N66_gene0134) 145899..146240 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
P4N66_RS00695 (P4N66_gene0135) 146322..147749 - 1428 WP_003083784.1 GABA permease -
P4N66_RS00700 (P4N66_gene0136) 147918..149411 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T279245 WP_003083773.1 NZ_CP123953:c144205-143924 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT279245 WP_003083775.1 NZ_CP123953:c144429-144202 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References