Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3591485..3592123 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QGM68_RS17160 Protein ID WP_000813794.1
Coordinates 3591947..3592123 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QGM68_RS17155 Protein ID WP_001270286.1
Coordinates 3591485..3591901 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS17135 (3586637) 3586637..3587578 - 942 WP_001251313.1 ABC transporter permease -
QGM68_RS17140 (3587579) 3587579..3588592 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
QGM68_RS17145 (3588610) 3588610..3589755 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QGM68_RS17150 (3590000) 3590000..3591406 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QGM68_RS17155 (3591485) 3591485..3591901 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QGM68_RS17160 (3591947) 3591947..3592123 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QGM68_RS17165 (3592345) 3592345..3592575 + 231 WP_000494244.1 YncJ family protein -
QGM68_RS17170 (3592667) 3592667..3594628 - 1962 WP_001752477.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QGM68_RS17175 (3594701) 3594701..3595237 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QGM68_RS17180 (3595329) 3595329..3596519 + 1191 WP_001236269.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3596559..3597707 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T279243 WP_000813794.1 NZ_CP123951:c3592123-3591947 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT279243 WP_001270286.1 NZ_CP123951:c3591901-3591485 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References