Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3540983..3541518 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag QGM68_RS16930 Protein ID WP_000222771.1
Coordinates 3541231..3541518 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag QGM68_RS16925 Protein ID WP_001139206.1
Coordinates 3540983..3541234 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS16915 (3536804) 3536804..3537501 + 698 WP_101780539.1 IS1 family transposase -
QGM68_RS16920 (3537512) 3537512..3540400 - 2889 Protein_3289 helicase-related protein -
QGM68_RS16925 (3540983) 3540983..3541234 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QGM68_RS16930 (3541231) 3541231..3541518 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QGM68_RS16935 (3541886) 3541886..3541999 - 114 Protein_3292 alkaline phosphatase -
QGM68_RS16940 (3541998) 3541998..3542203 + 206 Protein_3293 hypothetical protein -
QGM68_RS16945 (3542378) 3542378..3545893 - 3516 WP_077491875.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rhs/PAAR / vgrG/tssI 3533159..3574560 41401


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T279242 WP_000222771.1 NZ_CP123951:3541231-3541518 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT279242 WP_001139206.1 NZ_CP123951:3540983-3541234 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References