279233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2088499..2089153 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QGM68_RS10085 Protein ID WP_000244777.1
Coordinates 2088746..2089153 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QGM68_RS10080 Protein ID WP_000354046.1
Coordinates 2088499..2088765 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS10060 (2084468) 2084468..2085901 - 1434 WP_001753034.1 6-phospho-beta-glucosidase BglA -
QGM68_RS10065 (2085946) 2085946..2086257 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
QGM68_RS10070 (2086421) 2086421..2087080 + 660 WP_000250294.1 hemolysin III family protein -
QGM68_RS10075 (2087276) 2087276..2088256 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QGM68_RS10080 (2088499) 2088499..2088765 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QGM68_RS10085 (2088746) 2088746..2089153 + 408 WP_000244777.1 protein YgfX Toxin
QGM68_RS10090 (2089193) 2089193..2089714 - 522 WP_001055874.1 flavodoxin FldB -
QGM68_RS10095 (2089826) 2089826..2090722 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QGM68_RS10100 (2090747) 2090747..2091457 + 711 WP_001753033.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QGM68_RS10105 (2091463) 2091463..2093196 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T279233 WP_000244777.1 NZ_CP123951:2088746-2089153 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT279233 WP_000354046.1 NZ_CP123951:2088499-2088765 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References