Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 716680..717275 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QGM68_RS03450 Protein ID WP_000239579.1
Coordinates 716680..717030 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QGM68_RS03455 Protein ID WP_001223208.1
Coordinates 717024..717275 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS03430 (712128) 712128..713150 - 1023 WP_001353963.1 ABC transporter permease -
QGM68_RS03435 (713164) 713164..714666 - 1503 WP_000210561.1 sugar ABC transporter ATP-binding protein -
QGM68_RS03440 (714807) 714807..715763 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QGM68_RS03445 (716073) 716073..716603 + 531 WP_000055072.1 inorganic diphosphatase -
QGM68_RS03450 (716680) 716680..717030 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QGM68_RS03455 (717024) 717024..717275 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QGM68_RS03460 (717487) 717487..717828 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QGM68_RS03465 (717831) 717831..721610 - 3780 WP_000060898.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T279229 WP_000239579.1 NZ_CP123951:c717030-716680 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT279229 WP_001223208.1 NZ_CP123951:c717275-717024 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References