279228

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 654873..655687 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name yjhX Uniprot ID A0A6C9SL90
Locus tag QGM68_RS03140 Protein ID WP_001054375.1
Coordinates 654873..655130 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QGM68_RS03145 Protein ID WP_001309181.1
Coordinates 655142..655687 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS03115 (650161) 650161..651267 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
QGM68_RS03120 (651332) 651332..652312 + 981 WP_000991455.1 sialate O-acetylesterase -
QGM68_RS03125 (652422) 652422..652627 + 206 Protein_610 HNH endonuclease -
QGM68_RS03130 (652895) 652895..654135 - 1241 Protein_611 helicase YjhR -
QGM68_RS03135 (654251) 654251..654382 + 132 WP_001309182.1 hypothetical protein -
QGM68_RS03140 (654873) 654873..655130 + 258 WP_001054375.1 YjhX family toxin Toxin
QGM68_RS03145 (655142) 655142..655687 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QGM68_RS03150 (655743) 655743..656489 + 747 WP_000354252.1 class I SAM-dependent methyltransferase -
QGM68_RS03155 (656658) 656658..656876 + 219 Protein_616 hypothetical protein -
QGM68_RS03160 (656914) 656914..657030 + 117 Protein_617 VOC family protein -
QGM68_RS03165 (657275) 657275..658396 + 1122 WP_000010831.1 M42 family metallopeptidase -
QGM68_RS03170 (658393) 658393..658671 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QGM68_RS03175 (658683) 658683..659996 + 1314 WP_000460845.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9768.31 Da        Isoelectric Point: 11.0090

>T279228 WP_001054375.1 NZ_CP123951:654873-655130 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19938.86 Da        Isoelectric Point: 6.3277

>AT279228 WP_001309181.1 NZ_CP123951:655142-655687 [Escherichia coli]
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9SL90

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References