279227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 617925..618501 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QGM68_RS02945 Protein ID WP_001297643.1
Coordinates 618214..618501 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QGM68_RS02940 Protein ID WP_000063156.1
Coordinates 617925..618227 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS02925 (614521) 614521..616671 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QGM68_RS02930 (616721) 616721..616924 + 204 WP_000467859.1 YbdD/YjiX family protein -
QGM68_RS02935 (616935) 616935..617891 + 957 WP_001297640.1 GTPase -
QGM68_RS02940 (617925) 617925..618227 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QGM68_RS02945 (618214) 618214..618501 - 288 WP_001297643.1 BrnT family toxin Toxin
QGM68_RS02950 (618700) 618700..619397 - 698 Protein_575 IS1 family transposase -
QGM68_RS02955 (619454) 619454..619549 + 96 Protein_576 dienelactone hydrolase family protein -
QGM68_RS02960 (619695) 619695..620927 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
QGM68_RS02965 (620968) 620968..622248 + 1281 WP_032292030.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T279227 WP_001297643.1 NZ_CP123951:c618501-618214 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT279227 WP_000063156.1 NZ_CP123951:c618227-617925 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References