Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 92389..93007 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QGM68_RS00410 Protein ID WP_001291435.1
Coordinates 92789..93007 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QGM68_RS00405 Protein ID WP_000344800.1
Coordinates 92389..92763 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS00395 (87478) 87478..88671 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QGM68_RS00400 (88694) 88694..91843 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QGM68_RS00405 (92389) 92389..92763 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QGM68_RS00410 (92789) 92789..93007 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QGM68_RS00415 (93179) 93179..93730 + 552 WP_000102564.1 maltose O-acetyltransferase -
QGM68_RS00420 (93846) 93846..94316 + 471 WP_000136192.1 YlaC family protein -
QGM68_RS00425 (94480) 94480..96030 + 1551 WP_165899047.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QGM68_RS00430 (96072) 96072..96425 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QGM68_RS00440 (96804) 96804..97115 + 312 WP_000409911.1 MGMT family protein -
QGM68_RS00445 (97146) 97146..97718 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T279225 WP_001291435.1 NZ_CP123951:92789-93007 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT279225 WP_000344800.1 NZ_CP123951:92389-92763 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References