Detailed information of TA system TA279222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 14989..16324
• Replicon: plasmid unnamed2
• Accession: NZ_CP123914
• Organism: Acinetobacter bereziniae strain UCO-553

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: QHG52_RS21445
• Protein ID: WP_120376155.1
• Coordinates: 15377..16324 (+)
• Length: 316 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: QHG52_RS21440
• Protein ID: WP_120376154.1
• Coordinates: 14989..15384 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QHG52_RS21435	12804..13325	+	522	Protein_13	IS3 family transposase	-
QHG52_RS21440	14989..15384	+	396	WP_120376154.1	DUF6088 family protein	Antitoxin
QHG52_RS21445	15377..16324	+	948	WP_120376155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QHG52_RS21450	16560..18392	-	1833	WP_281104415.1	relaxase/mobilization nuclease domain-containing protein	-
QHG52_RS21455	18389..18712	-	324	WP_120376123.1	hypothetical protein	-
QHG52_RS21460	18988..19362	+	375	WP_120376124.1	hypothetical protein	-
QHG52_RS21465	19390..20685	-	1296	WP_120376125.1	Y-family DNA polymerase	-
QHG52_RS21470	20709..21287	-	579	WP_120376126.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	sul2 / tet(Y) / aph(6)-Id / aph(3'')-Ib	-	1..35184	35184
	-	flank	IS/Tn	-	-	13059..13343	284

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-299)

Antitoxin

• Protein of unknown function DUF6088 (10-129)

Sequences

Toxin

Protein

• Length: 316 a.a.
• Molecular weight: 36241.70 Da
• Isoelectric Point: 6.3975

>T279222 WP_120376155.1 NZ_CP123914:15377-16324 [Acinetobacter bereziniae]
MPDIKNVFADVADALGIGATSIVEKDYYVVELLRLLQSLEFETHDLVFAGGTSLAKANIQLNRMSEDVDIKIVPKPNIAL
SRSKAKVVRKQLLHQVQDKISQSDFFTIEEEPVVWDEYRYMELLIRYPQHFNQAPCLRPFIKLELVETDLLEPFESRSIT
SFVYDLAKKGKPVDAFPSVTIVSTSIEKLIAILRRTAAFARNAERADDESLVRHVYDYFKITYGKPQDFVYLGHLATKVI
KTDIERYGRQHTLMVEDPIAELLFGLNELSRNPLYKARFNNFVVPMVFGDKQISWQQAYSHFQDSVQQIFANLKL

Nucleotide

• Length: 948 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14884.31 Da
• Isoelectric Point: 10.6946

>AT279222 WP_120376154.1 NZ_CP123914:14989-15384 [Acinetobacter bereziniae]
MTTKAKMQMRIKRSKRYVFMRDDFNDIANYDQIGRVLRNLVQEGELIKVGYGIYTKARKNQITGKVMPACPEGADAVILE
ALKRLDVQVTLGEATEKYLSGQSTQIPAFTQIKTPRRFTRQLSVGRSQINA

Nucleotide

• Length: 396 bp