Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 14242..14786 Replicon plasmid pMYCCH.01
Accession NC_018022
Organism Mycobacterium chubuense NBB4

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MYCCH_RS26215 Protein ID WP_041783793.1
Coordinates 14490..14786 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MYCCH_RS30270 Protein ID WP_014805321.1
Coordinates 14242..14493 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYCCH_RS26180 9768..10565 + 798 WP_014805316.1 IS21-like element helper ATPase IstB -
MYCCH_RS26185 10624..10983 + 360 Protein_12 transposase -
MYCCH_RS30265 11021..11604 - 584 Protein_13 IS30 family transposase -
MYCCH_RS26190 11849..12136 + 288 Protein_14 transposase -
MYCCH_RS26195 12190..12744 + 555 WP_014805317.1 hypothetical protein -
MYCCH_RS26200 12916..13311 + 396 WP_158021525.1 relaxase domain-containing protein -
MYCCH_RS26205 13356..13625 + 270 WP_014805319.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MYCCH_RS26210 13622..13900 + 279 WP_014805320.1 type II toxin-antitoxin system RelE/ParE family toxin -
MYCCH_RS30270 14242..14493 + 252 WP_014805321.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MYCCH_RS26215 14490..14786 + 297 WP_041783793.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYCCH_RS26220 14888..16438 - 1551 WP_162131316.1 hypothetical protein -
MYCCH_RS26230 17486..17929 - 444 WP_014805325.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fbpA 1..615278 615278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11433.83 Da        Isoelectric Point: 5.9710

>T27922 WP_041783793.1 NC_018022:14490-14786 [Mycolicibacterium chubuense NBB4]
VSRYVLSPAARIDLEHIWDDTRQQWSDDQAERYTRELQRAIELVANNPLIGRPCDEVRAGYCKHAVGSHTLYYRVAAADL
IDVVRILHKRMDVDEHFD

Download         Length: 297 bp

>T27922 NC_018022:14490-14786 [Mycolicibacterium chubuense NBB4]
GTGAGTCGCTATGTGCTCTCCCCTGCCGCCCGTATCGACCTGGAGCACATCTGGGACGACACCAGGCAACAATGGAGCGA
CGACCAAGCTGAGCGCTACACCCGAGAGCTTCAGCGGGCGATCGAACTCGTGGCCAACAACCCTCTGATCGGCCGCCCCT
GTGATGAGGTCCGCGCCGGCTATTGCAAGCACGCCGTAGGCTCTCACACCCTGTACTACCGAGTGGCTGCCGCTGACCTG
ATCGACGTGGTGCGGATACTGCACAAGCGCATGGACGTCGACGAGCACTTCGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9260.15 Da        Isoelectric Point: 7.0120

>AT27922 WP_014805321.1 NC_018022:14242-14493 [Mycolicibacterium chubuense NBB4]
VGKNTSFSLDDHFTTFINNEVASGRYGSASDVVRAALRLLQDRETRLGALRQALVAGENSGESTPFDFDEFVTRQRARQP
NQR

Download         Length: 252 bp

>AT27922 NC_018022:14242-14493 [Mycolicibacterium chubuense NBB4]
GTGGGTAAGAACACCTCGTTCAGCCTCGATGATCACTTCACGACGTTCATCAATAATGAGGTTGCCTCGGGCCGGTACGG
CTCAGCGAGCGATGTGGTGCGTGCCGCGCTGCGGCTGCTCCAGGATCGTGAGACGCGTCTAGGTGCGCTGCGTCAAGCGC
TGGTTGCGGGGGAAAATAGTGGCGAATCAACACCGTTCGATTTCGATGAGTTCGTGACGCGCCAGCGCGCCCGACAACCG
AACCAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References