Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5264762..5265351 Replicon chromosome
Accession NZ_CP123909
Organism Pseudomonas atacamensis strain MGMM4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QG303_RS23980 Protein ID WP_281120398.1
Coordinates 5264762..5265013 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V8R847
Locus tag QG303_RS23985 Protein ID WP_016771749.1
Coordinates 5265010..5265351 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG303_RS23960 (QG303_23960) 5260080..5260640 - 561 WP_122880542.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
QG303_RS23965 (QG303_23965) 5260705..5262882 - 2178 WP_281120395.1 DUF1631 domain-containing protein -
QG303_RS23970 (QG303_23970) 5263150..5263998 + 849 WP_281120396.1 carboxylating nicotinate-nucleotide diphosphorylase -
QG303_RS23975 (QG303_23975) 5264107..5264406 - 300 WP_281120397.1 DUF6388 family protein -
QG303_RS23980 (QG303_23980) 5264762..5265013 + 252 WP_281120398.1 type II toxin-antitoxin system HicA family toxin Toxin
QG303_RS23985 (QG303_23985) 5265010..5265351 + 342 WP_016771749.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QG303_RS23995 (QG303_23995) 5265601..5267706 - 2106 WP_024011572.1 polyribonucleotide nucleotidyltransferase -
QG303_RS24000 (QG303_24000) 5267911..5268180 - 270 WP_016771751.1 30S ribosomal protein S15 -
QG303_RS24005 (QG303_24005) 5268324..5269241 - 918 WP_160767822.1 tRNA pseudouridine(55) synthase TruB -
QG303_RS24010 (QG303_24010) 5269246..5269647 - 402 WP_016771753.1 30S ribosome-binding factor RbfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5256043..5265351 9308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9370.83 Da        Isoelectric Point: 10.4725

>T279217 WP_281120398.1 NZ_CP123909:5264762-5265013 [Pseudomonas atacamensis]
MSKTEKLLAKLINWHSAFTWSELVTLLGRLGYSQLEGSGSRIKFDNGDPNALINLHKPHPGNEIKTYARRQIIEQLKKGG
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12594.21 Da        Isoelectric Point: 5.9655

>AT279217 WP_016771749.1 NZ_CP123909:5265010-5265351 [Pseudomonas atacamensis]
MSSQLHYKGYVGSIEASTEDKCLFGKLLFIRALVNYEGQTVAELEAAFREAVDDYLQTCEQLGQKPEIPCKGSFNVRIGH
DLHLAAALAATRQNVSLNDLTRQALNEYLQHHA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V8R847

References