Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 4416466..4417505 | Replicon | chromosome |
| Accession | NZ_CP123909 | ||
| Organism | Pseudomonas atacamensis strain MGMM4 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | QG303_RS20070 | Protein ID | WP_076566634.1 |
| Coordinates | 4416930..4417505 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | QG303_RS20065 | Protein ID | WP_160768170.1 |
| Coordinates | 4416466..4416933 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QG303_RS20040 (QG303_20040) | 4412204..4413028 | + | 825 | WP_039763624.1 | ion transporter | - |
| QG303_RS20045 (QG303_20045) | 4413133..4414131 | + | 999 | WP_110601117.1 | sulfate ABC transporter substrate-binding protein | - |
| QG303_RS20050 (QG303_20050) | 4414298..4415485 | + | 1188 | WP_024012134.1 | MFS transporter | - |
| QG303_RS20055 (QG303_20055) | 4415666..4416070 | - | 405 | WP_130901292.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| QG303_RS20060 (QG303_20060) | 4416070..4416264 | - | 195 | WP_130901293.1 | type II toxin-antitoxin system HicA family toxin | - |
| QG303_RS20065 (QG303_20065) | 4416466..4416933 | + | 468 | WP_160768170.1 | helix-turn-helix domain-containing protein | Antitoxin |
| QG303_RS20070 (QG303_20070) | 4416930..4417505 | + | 576 | WP_076566634.1 | PIN domain-containing protein | Toxin |
| QG303_RS20075 (QG303_20075) | 4417551..4417955 | - | 405 | WP_016771039.1 | hypothetical protein | - |
| QG303_RS20080 (QG303_20080) | 4417981..4419180 | - | 1200 | WP_281119869.1 | c-type cytochrome biogenesis protein CcmI | - |
| QG303_RS20085 (QG303_20085) | 4419177..4419647 | - | 471 | WP_016771041.1 | cytochrome c-type biogenesis protein CcmH | - |
| QG303_RS20090 (QG303_20090) | 4419644..4420180 | - | 537 | WP_016771042.1 | DsbE family thiol:disulfide interchange protein | - |
| QG303_RS20095 (QG303_20095) | 4420177..4422165 | - | 1989 | WP_258605559.1 | heme lyase CcmF/NrfE family subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21688.71 Da Isoelectric Point: 6.1390
>T279216 WP_076566634.1 NZ_CP123909:4416930-4417505 [Pseudomonas atacamensis]
VRHSSFTAVYDACVLYPAPLRDFLMWLALSGLYRARWTQEIHHEWKRNLLKNRSDLTLEQLDRTSQLMDLAIPDACIDGY
EDLVSGLTLPDENDRHVLAAAIRCGADVIVTFNLKDFPTRHLAPYGIEAQHPDEFVENLFHLDSAAVVAAAQSQRRQLKT
PNVEVDKYLGFLQRQGLVESVKALGNYRAIL
VRHSSFTAVYDACVLYPAPLRDFLMWLALSGLYRARWTQEIHHEWKRNLLKNRSDLTLEQLDRTSQLMDLAIPDACIDGY
EDLVSGLTLPDENDRHVLAAAIRCGADVIVTFNLKDFPTRHLAPYGIEAQHPDEFVENLFHLDSAAVVAAAQSQRRQLKT
PNVEVDKYLGFLQRQGLVESVKALGNYRAIL
Download Length: 576 bp
Antitoxin
Download Length: 156 a.a. Molecular weight: 17253.67 Da Isoelectric Point: 6.6497
>AT279216 WP_160768170.1 NZ_CP123909:4416466-4416933 [Pseudomonas atacamensis]
MTTATPSAINLPVEREVKAAIEGQRALSAFLTTAFETQRIQIFDEQNEAHSVELPTSALRLLSDILAALAQGNAVKVVPI
HAELTTQEAADLLNVSRPHMIKLLERGEISYHKTGKHRRVRFADLMEYKTRRDTASEQAMTLLAEQAQALRTGYE
MTTATPSAINLPVEREVKAAIEGQRALSAFLTTAFETQRIQIFDEQNEAHSVELPTSALRLLSDILAALAQGNAVKVVPI
HAELTTQEAADLLNVSRPHMIKLLERGEISYHKTGKHRRVRFADLMEYKTRRDTASEQAMTLLAEQAQALRTGYE
Download Length: 468 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|