Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4415666..4416264 Replicon chromosome
Accession NZ_CP123909
Organism Pseudomonas atacamensis strain MGMM4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QG303_RS20060 Protein ID WP_130901293.1
Coordinates 4416070..4416264 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QG303_RS20055 Protein ID WP_130901292.1
Coordinates 4415666..4416070 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG303_RS20035 (QG303_20035) 4411268..4412182 + 915 WP_281119865.1 urea transporter -
QG303_RS20040 (QG303_20040) 4412204..4413028 + 825 WP_039763624.1 ion transporter -
QG303_RS20045 (QG303_20045) 4413133..4414131 + 999 WP_110601117.1 sulfate ABC transporter substrate-binding protein -
QG303_RS20050 (QG303_20050) 4414298..4415485 + 1188 WP_024012134.1 MFS transporter -
QG303_RS20055 (QG303_20055) 4415666..4416070 - 405 WP_130901292.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QG303_RS20060 (QG303_20060) 4416070..4416264 - 195 WP_130901293.1 type II toxin-antitoxin system HicA family toxin Toxin
QG303_RS20065 (QG303_20065) 4416466..4416933 + 468 WP_160768170.1 helix-turn-helix domain-containing protein -
QG303_RS20070 (QG303_20070) 4416930..4417505 + 576 WP_076566634.1 PIN domain-containing protein -
QG303_RS20075 (QG303_20075) 4417551..4417955 - 405 WP_016771039.1 hypothetical protein -
QG303_RS20080 (QG303_20080) 4417981..4419180 - 1200 WP_281119869.1 c-type cytochrome biogenesis protein CcmI -
QG303_RS20085 (QG303_20085) 4419177..4419647 - 471 WP_016771041.1 cytochrome c-type biogenesis protein CcmH -
QG303_RS20090 (QG303_20090) 4419644..4420180 - 537 WP_016771042.1 DsbE family thiol:disulfide interchange protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-53)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7249.25 Da        Isoelectric Point: 10.2204

>T279215 WP_130901293.1 NZ_CP123909:c4416264-4416070 [Pseudomonas atacamensis]
MKELEEAGWSLDRVAGSHYIFTHRYNPNTIAVPHPKKDLPLGTVKSIRRRAGLFSPPTRHEGDP

Download         Length: 195 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14804.86 Da        Isoelectric Point: 4.5789

>AT279215 WP_130901292.1 NZ_CP123909:c4416070-4415666 [Pseudomonas atacamensis]
MQYPICIEWGDENTAIGIQIPDIPGAVTVGDSFEEAYNAAVEVAHLMLQEIAAAGQAIPMPTSAAAHRNHPDFAEMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References