Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1917534..1919158 Replicon chromosome
Accession NZ_CP123909
Organism Pseudomonas atacamensis strain MGMM4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QG303_RS08920 Protein ID WP_281121088.1
Coordinates 1917809..1919158 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6I0CP94
Locus tag QG303_RS08915 Protein ID WP_071171374.1
Coordinates 1917534..1917812 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG303_RS08885 (QG303_08885) 1912975..1913598 + 624 WP_281121085.1 FMN-binding negative transcriptional regulator -
QG303_RS08890 (QG303_08890) 1913609..1914055 + 447 WP_024014846.1 GNAT family N-acetyltransferase -
QG303_RS08895 (QG303_08895) 1914068..1914739 + 672 WP_071171378.1 GNAT family protein -
QG303_RS08900 (QG303_08900) 1914860..1915762 - 903 WP_281121086.1 homocysteine S-methyltransferase family protein -
QG303_RS08905 (QG303_08905) 1915893..1916693 + 801 WP_281121496.1 ABC transporter substrate-binding protein -
QG303_RS08910 (QG303_08910) 1916690..1917526 + 837 WP_281121087.1 amino acid ABC transporter permease -
QG303_RS08915 (QG303_08915) 1917534..1917812 - 279 WP_071171374.1 helix-turn-helix transcriptional regulator Antitoxin
QG303_RS08920 (QG303_08920) 1917809..1919158 - 1350 WP_281121088.1 HipA domain-containing protein Toxin
QG303_RS08925 (QG303_08925) 1919527..1921764 + 2238 WP_281121498.1 autotransporter outer membrane beta-barrel domain-containing protein -
QG303_RS08930 (QG303_08930) 1921975..1923783 - 1809 WP_258710755.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49825.36 Da        Isoelectric Point: 5.0690

>T279211 WP_281121088.1 NZ_CP123909:c1919158-1917809 [Pseudomonas atacamensis]
MYNLTIQIFTAGQWHDAMILDFDDPEKGFESRCSFGYEADYLVENIEFIGSPFSQAVSALYPLDWEGRRAKTPAFVHDIA
PAGAAKRFLLARLGQERPAEISADLFLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREEVIGRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENSAGLLYPDAVLDDEEVRQHWFVKFARNRGGQTDQDILRSEFHYYKALQTLGIETVAAEGLALE
EANKPSLWMRRFDRQVKDGAVSRFAVESIYSLAEVTTPGSAMNHLDVIRMLAGLWRKAGQASQIAGLVADYLRRDLINKI
LGNSDNHGRNTAIIRQENAFQLAPIYDLAPMVMDDEGVTRTTKWPRELERAGDVDWRGVCRVLADSADPHDSLAGLDASA
LFEGLRADARRLAALPDILAASGLPARTMNHPSVHLKNLEQRLKEWDLQ

Download         Length: 1350 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10318.09 Da        Isoelectric Point: 10.7364

>AT279211 WP_071171374.1 NZ_CP123909:c1917812-1917534 [Pseudomonas atacamensis]
MSLTVLERTALIESIQQSLAEGTLEIGDAVRRLRVEVTGLHQSQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGM
KMGVVRIRRDTI

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6I0CP94

References