279209

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pmenA/ParE(toxin)
Location 1261783..1263313 Replicon chromosome
Accession NZ_CP123909
Organism Pseudomonas atacamensis strain MGMM4

Toxin (Protein)


Gene name relE Uniprot ID A0A554AGI8
Locus tag QG303_RS05820 Protein ID WP_041477706.1
Coordinates 1261783..1262079 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID V8R4A4
Locus tag QG303_RS05825 Protein ID WP_024014473.1
Coordinates 1262228..1263313 (+) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QG303_RS05790 (QG303_05790) 1257367..1257828 + 462 WP_016773002.1 GNAT family N-acetyltransferase -
QG303_RS05795 (QG303_05795) 1258057..1258707 + 651 WP_281120935.1 DedA family protein -
QG303_RS05800 (QG303_05800) 1258712..1259524 + 813 WP_122610988.1 zinc-dependent peptidase -
QG303_RS05805 (QG303_05805) 1259637..1260164 + 528 WP_003205933.1 inorganic diphosphatase -
QG303_RS05810 (QG303_05810) 1260382..1261128 + 747 WP_073475694.1 S24 family peptidase -
QG303_RS05815 (QG303_05815) 1261554..1261793 + 240 WP_039761862.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
QG303_RS05820 (QG303_05820) 1261783..1262079 + 297 WP_041477706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QG303_RS05825 (QG303_05825) 1262228..1263313 + 1086 WP_024014473.1 macro domain-containing protein Antitoxin
QG303_RS05830 (QG303_05830) 1263359..1264171 - 813 WP_110646086.1 DUF2135 domain-containing protein -
QG303_RS05835 (QG303_05835) 1264175..1265794 - 1620 WP_281120937.1 DUF2300 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11667.51 Da        Isoelectric Point: 9.6904

>T279209 WP_041477706.1 NZ_CP123909:1261783-1262079 [Pseudomonas atacamensis]
MTYELEFDRRALKEWNKLGDTVRQQFKKKLAEVLENPRIEANRLRELPDCYKVKLKSAGYRLIYQVLDHEILVFVVAIGK
REREAAYEVAQDRLPSRT

Download         Length: 297 bp

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 40413.39 Da        Isoelectric Point: 6.6149

>AT279209 WP_024014473.1 NZ_CP123909:1262228-1263313 [Pseudomonas atacamensis]
MIRFTQGNLLEAKTEALVNTVNTVGVMGKGIALMFKERFAQNYRVYAAACKAGEVETGKMHVTATNELDGPRWIVNFPTK
RHWRSPSQMAWITEGLHDLRRFLLENDVKSVAVPPLGAGNGGLKWPDVREQIVEVLGDLDADVLVFEPSNQYLNVAKRAG
VEKLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERAIEQLPDTENLLNLKFVAHKYGPYANRLEHLLDNLDGSYLH
CDKRISDAGINDVIWFDQDRKAFLQTYLKTEAKAYSQALERTAQLIDGFESPFGMELLATVDWLLSQEGVSATVPALREA
LKHWEGGAGAAARKSKLFDDQALDIALKRLTSSTFRPGLAA

Download         Length: 1086 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A554AGI8

Antitoxin

Source ID Structure
AlphaFold DB V8R4A4

References