Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5054056..5054617 Replicon chromosome
Accession NZ_CP123897
Organism Methylomonas sp. UP202

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QC632_RS22345 Protein ID WP_281021579.1
Coordinates 5054381..5054617 (-) Length 79 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QC632_RS22340 Protein ID WP_281021578.1
Coordinates 5054056..5054394 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC632_RS22315 (QC632_22315) 5050304..5050747 + 444 WP_071159263.1 hypothetical protein -
QC632_RS22320 (QC632_22320) 5050992..5051600 + 609 WP_281021574.1 hypothetical protein -
QC632_RS22325 (QC632_22325) 5051650..5053275 - 1626 WP_281021575.1 sulfate adenylyltransferase subunit CysN -
QC632_RS22330 (QC632_22330) 5053313..5053465 - 153 WP_281021576.1 hypothetical protein -
QC632_RS22335 (QC632_22335) 5053690..5053893 - 204 WP_281021577.1 hypothetical protein -
QC632_RS22340 (QC632_22340) 5054056..5054394 - 339 WP_281021578.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QC632_RS22345 (QC632_22345) 5054381..5054617 - 237 WP_281021579.1 type II toxin-antitoxin system HicA family toxin Toxin
QC632_RS22350 (QC632_22350) 5054670..5055578 - 909 WP_281021580.1 sulfate adenylyltransferase subunit CysD -
QC632_RS22355 (QC632_22355) 5055665..5056078 + 414 WP_281021581.1 hypothetical protein -
QC632_RS22360 (QC632_22360) 5056203..5057561 + 1359 WP_064030757.1 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase -
QC632_RS22365 (QC632_22365) 5057673..5058110 - 438 WP_281021582.1 thioredoxin TrxC -
QC632_RS22370 (QC632_22370) 5058136..5059080 - 945 WP_281021583.1 zinc metalloprotease HtpX -
QC632_RS22375 (QC632_22375) 5059083..5059388 - 306 WP_064030760.1 chaperone modulator CbpM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(19-71)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 9329.92 Da        Isoelectric Point: 10.0665

>T279203 WP_281021579.1 NZ_CP123897:c5054617-5054381 [Methylomonas sp. UP202]
VSKKQKLIEKFKSDSEFTWQELERMMLLLGFEKQEGDGSRVKFYKPELTVSIHKPHPDKSIKHYVRKEILARLKDELL

Download         Length: 237 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12806.41 Da        Isoelectric Point: 6.7049

>AT279203 WP_281021578.1 NZ_CP123897:c5054394-5054056 [Methylomonas sp. UP202]
MNCFSYKGYQGSVETSIQDKCLYGKLLNITDLILYEGNTVDELEQNFKASVDDYLEHCKQQNKPPKKPFKGSFNVRIGQE
LHEKASKRASEIGKSLNEYIKDIVQKDTESHA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References