Detailed information of TA system TA027920

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 3666295..3666800
• Replicon: chromosome
• Accession: NC_018020
• Organism: Turneriella parva DSM 21527

Toxin (Protein)

• Gene name: relB
• Uniprot ID: I4BA53
• Locus tag: TURPA_RS17740
• Protein ID: WP_014804642.1
• Coordinates: 3666543..3666800 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I4BA52
• Locus tag: TURPA_RS17735
• Protein ID: WP_014804641.1
• Coordinates: 3666295..3666543 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TURPA_RS17710	3661361..3662020	+	660	WP_014804636.1	hypothetical protein	-
TURPA_RS23195	3663346..3663891	+	546	WP_014804638.1	SH3 domain-containing protein	-
TURPA_RS23700	3664251..3664436	-	186	WP_157210576.1	hypothetical protein	-
TURPA_RS17725	3664755..3665033	+	279	WP_014804639.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
TURPA_RS22230	3665017..3665418	+	402	WP_014804640.1	putative toxin-antitoxin system toxin component, PIN family	-
TURPA_RS17735	3666295..3666543	+	249	WP_014804641.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
TURPA_RS17740	3666543..3666800	+	258	WP_014804642.1	Txe/YoeB family addiction module toxin	Toxin
TURPA_RS17745	3667102..3667581	+	480	WP_014804511.1	type II toxin-antitoxin system VapC family toxin	-
TURPA_RS17750	3667571..3667750	+	180	WP_014804512.1	hypothetical protein	-
TURPA_RS17755	3668074..3668397	+	324	WP_041948673.1	type II toxin-antitoxin system RelE/ParE family toxin	-
TURPA_RS17760	3668408..3668743	+	336	WP_014804644.1	helix-turn-helix domain-containing protein	-
TURPA_RS17775	3670176..3670475	-	300	WP_014804645.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3455166..3670475	215309

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10256.70 Da
• Isoelectric Point: 8.8304

>T27920 WP_014804642.1 NC_018020:3666543-3666800 [Turneriella parva DSM 21527]
MNVLFTDAGWEDYVHWQSEDRKTLKKINDLIRDIKRSPYEGIGKPEPLKHQLQGYWSRRIDPEHRLVYQVEGNKTLVIIA
CRYHY

Nucleotide

• Length: 258 bp

>T27920 NC_018020:3666543-3666800 [Turneriella parva DSM 21527]
ATGAATGTATTATTTACGGATGCCGGCTGGGAGGACTATGTTCACTGGCAGTCAGAAGATCGAAAGACATTGAAAAAAAT
TAATGATTTAATCAGAGATATAAAACGCTCTCCATATGAGGGTATTGGGAAGCCTGAGCCCCTGAAACACCAATTACAAG
GCTATTGGTCACGCAGAATTGACCCGGAGCATAGACTTGTATATCAGGTCGAAGGCAACAAGACACTTGTCATTATAGCC
TGCCGCTATCACTACTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9466.90 Da
• Isoelectric Point: 9.6592

>AT27920 WP_014804641.1 NC_018020:3666295-3666543 [Turneriella parva DSM 21527]
MDAVSYSDLRKNLKKYMDDVYTGHYPLIITRKNDENVVMISLDEFNSLQETNYLLASDANVKHLKKSIAQHRAGKLKQVK
IP

Nucleotide

• Length: 249 bp

>AT27920 NC_018020:3666295-3666543 [Turneriella parva DSM 21527]
ATGGATGCGGTTTCTTACAGTGATCTGAGGAAGAACCTTAAGAAGTACATGGACGATGTCTACACAGGGCATTATCCCCT
CATCATTACGAGAAAAAACGATGAAAATGTTGTAATGATTTCGTTAGATGAGTTTAATTCGTTGCAAGAAACAAATTACC
TTTTAGCCTCTGACGCCAATGTCAAACACTTGAAAAAGTCCATCGCGCAGCACCGAGCAGGTAAATTGAAGCAAGTAAAG
ATTCCTTGA

Structures

Toxin

• AlphaFold DB: I4BA53

Antitoxin

• AlphaFold DB: I4BA52