Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3331373..3331954 Replicon chromosome
Accession NZ_CP123897
Organism Methylomonas sp. UP202

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag QC632_RS14885 Protein ID WP_281020599.1
Coordinates 3331655..3331954 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QC632_RS14880 Protein ID WP_281020598.1
Coordinates 3331373..3331651 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC632_RS14855 (QC632_14855) 3326749..3327600 - 852 WP_281020593.1 RNA polymerase sigma factor RpoH -
QC632_RS14860 (QC632_14860) 3327842..3329503 + 1662 WP_281020594.1 glutamine--tRNA ligase/YqeY domain fusion protein -
QC632_RS14865 (QC632_14865) 3329598..3330584 + 987 WP_281020595.1 toll/interleukin-1 receptor domain-containing protein -
QC632_RS14870 (QC632_14870) 3330663..3330890 + 228 WP_281020596.1 addiction module protein -
QC632_RS14875 (QC632_14875) 3330887..3331180 + 294 WP_281020597.1 type II toxin-antitoxin system RelE/ParE family toxin -
QC632_RS14880 (QC632_14880) 3331373..3331651 - 279 WP_281020598.1 putative addiction module antidote protein Antitoxin
QC632_RS14885 (QC632_14885) 3331655..3331954 - 300 WP_281020599.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QC632_RS14890 (QC632_14890) 3332238..3332570 + 333 WP_281020600.1 hypothetical protein -
QC632_RS14895 (QC632_14895) 3332690..3333247 + 558 WP_281020601.1 Uma2 family endonuclease -
QC632_RS14900 (QC632_14900) 3333268..3334152 + 885 WP_281020602.1 fructosamine kinase family protein -
QC632_RS14905 (QC632_14905) 3334246..3336894 - 2649 WP_281020603.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3311582..3331954 20372


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11351.95 Da        Isoelectric Point: 10.1005

>T279199 WP_281020599.1 NZ_CP123897:c3331954-3331655 [Methylomonas sp. UP202]
MKYELQSTQTFAEWFSRQKDKTVKNQLLSRLARIENGNFGDSKTLSANLFELRCFFGGGIRLYYTIRNQRIVLLLAGGDK
SSQNKDIEKAKAILNSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9849.19 Da        Isoelectric Point: 5.1147

>AT279199 WP_281020598.1 NZ_CP123897:c3331651-3331373 [Methylomonas sp. UP202]
MPETITAFDIAEHLETEADVREFLRETASNGSPSDFIHALNIAARAKGMSEVAKQAGVTRASLYKSLAEGGNPRFETVAK
IVEALGCKLIVS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References