Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpB-pemI/PRK09812-MazE
Location 2923179..2923771 Replicon chromosome
Accession NZ_CP123897
Organism Methylomonas sp. UP202

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag QC632_RS12725 Protein ID WP_281020266.1
Coordinates 2923424..2923771 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag QC632_RS12720 Protein ID WP_281020265.1
Coordinates 2923179..2923424 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC632_RS12700 (QC632_12700) 2919116..2919331 - 216 WP_281020261.1 PRTRC system protein C -
QC632_RS12705 (QC632_12705) 2919343..2919774 - 432 WP_281020262.1 PRTRC system protein E -
QC632_RS12710 (QC632_12710) 2919777..2921717 - 1941 WP_281020263.1 PRTRC system ParB family protein -
QC632_RS12715 (QC632_12715) 2921895..2922894 + 1000 WP_281020264.1 IS5 family transposase -
QC632_RS12720 (QC632_12720) 2923179..2923424 + 246 WP_281020265.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QC632_RS12725 (QC632_12725) 2923424..2923771 + 348 WP_281020266.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QC632_RS12730 (QC632_12730) 2924286..2925161 - 876 WP_256604544.1 LysR family transcriptional regulator -
QC632_RS12735 (QC632_12735) 2925281..2925607 + 327 WP_033159460.1 EthD family reductase -
QC632_RS12740 (QC632_12740) 2925650..2926255 + 606 WP_281020267.1 hypothetical protein -
QC632_RS12745 (QC632_12745) 2926301..2927194 + 894 WP_281020268.1 poly(3-hydroxybutyrate) depolymerase -
QC632_RS12750 (QC632_12750) 2927559..2927918 - 360 WP_281020269.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - groEL / htpB / htpB / tviB 2808982..3217664 408682


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12381.27 Da        Isoelectric Point: 9.2086

>T279198 WP_281020266.1 NZ_CP123897:2923424-2923771 [Methylomonas sp. UP202]
MAYLPNRGDIVHLAFHPSSGREMKGPHFGLVLSGKVFNQQGLAMICPISQGAAAAARTYGTVVTLSGAGTDTQGAVHCHQ
LKSLDWRARKVRLKETAPQQVVDEALARIEAILFE

Download         Length: 348 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8879.28 Da        Isoelectric Point: 5.8086

>AT279198 WP_281020265.1 NZ_CP123897:2923179-2923424 [Methylomonas sp. UP202]
MRQTLRKAGGSLVMTVPKAFVDQNGLGEGSQVELHLLGRKMTVEAPTRPRYKLADLMAEMPEGLPRVEGWDDMPTVGLEN
G

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References