Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2359679..2361171 Replicon chromosome
Accession NZ_CP123897
Organism Methylomonas sp. UP202

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag QC632_RS10280 Protein ID WP_281023119.1
Coordinates 2359909..2361171 (+) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A2N0V9P0
Locus tag QC632_RS10275 Protein ID WP_033156241.1
Coordinates 2359679..2359912 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC632_RS10255 (QC632_10255) 2355331..2355726 - 396 WP_281023116.1 type II toxin-antitoxin system VapC family toxin -
QC632_RS10260 (QC632_10260) 2355723..2355989 - 267 WP_197471828.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QC632_RS10265 (QC632_10265) 2356536..2358893 - 2358 WP_281023117.1 DEAD/DEAH box helicase family protein -
QC632_RS10270 (QC632_10270) 2358886..2359437 - 552 WP_281023118.1 hypothetical protein -
QC632_RS10275 (QC632_10275) 2359679..2359912 + 234 WP_033156241.1 helix-turn-helix transcriptional regulator Antitoxin
QC632_RS10280 (QC632_10280) 2359909..2361171 + 1263 WP_281023119.1 type II toxin-antitoxin system HipA family toxin Toxin
QC632_RS10290 (QC632_10290) 2361493..2362674 - 1182 WP_281023120.1 pyridoxal phosphate-dependent aminotransferase -
QC632_RS10295 (QC632_10295) 2362758..2364209 - 1452 WP_281023121.1 exodeoxyribonuclease I -
QC632_RS10300 (QC632_10300) 2364324..2364917 + 594 WP_281023122.1 SRPBCC family protein -
QC632_RS10305 (QC632_10305) 2365005..2365958 + 954 WP_168030574.1 YncE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-376)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 46411.43 Da        Isoelectric Point: 7.0911

>T279197 WP_281023119.1 NZ_CP123897:2359909-2361171 [Methylomonas sp. UP202]
MSYLLAVYLFDRRVGDLALVEGRLQFCYCADWLQHADAVPLSCSLPLQVEVFNDQQTRPFFAGLLPEGKLRQLIARQFQV
SKQNDFALLNHIGGECAGAVSLLSPDRLPAVSEPANEIDWLSDSDILALLDELPQRPMLAGQDGFRLSLAGAQDKLPVVF
DGQRIGLPRNGTPSSHILKPAIAAVEDSVINEGFCLALAGAMQFQTAQSRICAIRDRSFLLVERYDRTQAAIGQRLRLHQ
EDFCQALGIVPELKYQNEGGPGLDQCFDLVRRVTRPSAPQVLRLLDAVIFNALIGNHDAHAKNFSILYADKCAVLAPLYD
VLSTAVYPSLTPKMAMQLGGKYKFSEVQARHWDRFAQAAGLSVAQTRKRILGLCQRLPLVARTLQASADHDFVGNPAVEQ
IVQLIEQRAALTVRRLNDKT

Download         Length: 1263 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8257.62 Da        Isoelectric Point: 4.6082

>AT279197 WP_033156241.1 NZ_CP123897:2359679-2359912 [Methylomonas sp. UP202]
MINIQSTQQLGQALRSARKQLELTQSELALAAGVGVRFIVDLEAGKPTVRLETVMRVIEALGGQVMLDGLPDITEAP

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N0V9P0

References