Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2352849..2353438 Replicon chromosome
Accession NZ_CP123897
Organism Methylomonas sp. UP202

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QC632_RS10240 Protein ID WP_281023112.1
Coordinates 2353055..2353438 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A172U6T4
Locus tag QC632_RS10235 Protein ID WP_064021136.1
Coordinates 2352849..2353058 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC632_RS10225 (QC632_10225) 2349671..2351485 + 1815 WP_281023110.1 ABC transporter ATP-binding protein -
QC632_RS10230 (QC632_10230) 2352217..2352747 + 531 WP_281023111.1 transposase -
QC632_RS10235 (QC632_10235) 2352849..2353058 + 210 WP_064021136.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QC632_RS10240 (QC632_10240) 2353055..2353438 + 384 WP_281023112.1 type II toxin-antitoxin system VapC family toxin Toxin
QC632_RS10245 (QC632_10245) 2353451..2353858 + 408 WP_281023113.1 transposase -
QC632_RS10250 (QC632_10250) 2354007..2355095 - 1089 WP_281023115.1 hypothetical protein -
QC632_RS10255 (QC632_10255) 2355331..2355726 - 396 WP_281023116.1 type II toxin-antitoxin system VapC family toxin -
QC632_RS10260 (QC632_10260) 2355723..2355989 - 267 WP_197471828.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14069.34 Da        Isoelectric Point: 5.6943

>T279196 WP_281023112.1 NZ_CP123897:2353055-2353438 [Methylomonas sp. UP202]
MILVDTSVWIDHFKNRNEDLVRLLVTDSALIHPLIVAELACGTPPAPRTQTLNNLRQLRCCNQAGLQEVEDFIEREALYG
LGCGLIDLQLLASVLITPGAKLWTLDKRLAKLAERFGVAYQASPTTN

Download         Length: 384 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7816.01 Da        Isoelectric Point: 5.0490

>AT279196 WP_064021136.1 NZ_CP123897:2352849-2353058 [Methylomonas sp. UP202]
MRTTVTIDDTLYQKALEMADPDMDKAEIFREAMKTFVRIQAAKRLAALGGTMPEMADIPRDRRQTEPSA

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A172U6T4

References