Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 1391443..1392266 Replicon chromosome
Accession NZ_CP123897
Organism Methylomonas sp. UP202

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag QC632_RS06085 Protein ID WP_281022560.1
Coordinates 1391730..1392266 (+) Length 179 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A177P7Z8
Locus tag QC632_RS06080 Protein ID WP_064024751.1
Coordinates 1391443..1391730 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC632_RS06070 (QC632_06070) 1388106..1389446 + 1341 WP_281023372.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
QC632_RS06075 (QC632_06075) 1389566..1391308 + 1743 WP_281022559.1 class I SAM-dependent DNA methyltransferase -
QC632_RS06080 (QC632_06080) 1391443..1391730 + 288 WP_064024751.1 DUF1778 domain-containing protein Antitoxin
QC632_RS06085 (QC632_06085) 1391730..1392266 + 537 WP_281022560.1 GNAT family N-acetyltransferase Toxin
QC632_RS06090 (QC632_06090) 1392263..1393540 + 1278 WP_281022561.1 restriction endonuclease subunit S -
QC632_RS06095 (QC632_06095) 1393537..1394172 + 636 WP_281022562.1 hypothetical protein -
QC632_RS06100 (QC632_06100) 1394437..1394673 + 237 WP_281022563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QC632_RS06105 (QC632_06105) 1394661..1394975 + 315 WP_281022564.1 type II toxin-antitoxin system PemK/MazF family toxin -
QC632_RS06110 (QC632_06110) 1395262..1395525 + 264 WP_281022565.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(16-79)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 19299.32 Da        Isoelectric Point: 9.1795

>T279195 WP_281022560.1 NZ_CP123897:1391730-1392266 [Methylomonas sp. UP202]
VLSSPTLLTAEHRRHDFACGVDALDDWLKRRALSNQFSGASRTYVVTDESRVVGYYCLASGAMALNQALPALKRNMPDPV
PMAILCRLAVDFAWRGRGLGVALLQDAVLRTLRAASIVGIRGLLVHALSEPAKAFYQHHGFVASPTQPMTLILSLKHPLN
PATTETSADQQLIKDGPT

Download         Length: 537 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10663.97 Da        Isoelectric Point: 7.2029

>AT279195 WP_064024751.1 NZ_CP123897:1391443-1391730 [Methylomonas sp. UP202]
MAHRASNPDSPTHAVNLRVRGDVRALIDQAAKAQGKTRSDFMIDAARRAAEESLLDQALVRVDWETYQQFLQVLDQPATG
EGYDRLMAARKPWQA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A177P7Z8

References