Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2691787..2692316 Replicon chromosome
Accession NZ_CP123852
Organism Staphylococcus aureus strain 5812R

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NRK31_RS13275 Protein ID WP_000621175.1
Coordinates 2691954..2692316 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NRK31_RS13270 Protein ID WP_000948331.1
Coordinates 2691787..2691957 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRK31_RS13240 (2686823) 2686823..2687383 + 561 WP_001092409.1 K(+)-transporting ATPase subunit C -
NRK31_RS13245 (2687592) 2687592..2688071 + 480 WP_001287079.1 hypothetical protein -
NRK31_RS13250 (2688064) 2688064..2689647 + 1584 WP_001294620.1 PH domain-containing protein -
NRK31_RS13255 (2689634) 2689634..2690125 + 492 WP_001205912.1 PH domain-containing protein -
NRK31_RS13260 (2690129) 2690129..2690488 + 360 WP_000581197.1 holo-ACP synthase -
NRK31_RS13265 (2690554) 2690554..2691702 + 1149 WP_001281154.1 alanine racemase -
NRK31_RS13270 (2691787) 2691787..2691957 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NRK31_RS13275 (2691954) 2691954..2692316 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NRK31_RS13280 (2692666) 2692666..2693667 + 1002 WP_042727554.1 PP2C family protein-serine/threonine phosphatase -
NRK31_RS13285 (2693786) 2693786..2694112 + 327 WP_001052491.1 anti-sigma factor antagonist -
NRK31_RS13290 (2694114) 2694114..2694593 + 480 WP_001190829.1 anti-sigma B factor RsbW -
NRK31_RS13295 (2694568) 2694568..2695338 + 771 WP_001041102.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T279178 WP_000621175.1 NZ_CP123852:2691954-2692316 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT279178 WP_000948331.1 NZ_CP123852:2691787-2691957 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References