Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2672053..2672567 Replicon chromosome
Accession NZ_CP123852
Organism Staphylococcus aureus strain 5812R

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NRK31_RS13185 Protein ID WP_000581792.1
Coordinates 2672358..2672567 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NRK31_RS13180 Protein ID WP_000138932.1
Coordinates 2672053..2672346 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRK31_RS13160 (2667524) 2667524..2668165 + 642 WP_000483153.1 thiamine phosphate synthase -
NRK31_RS13165 (2668251) 2668251..2669123 + 873 WP_000725802.1 membrane protein insertase YidC -
NRK31_RS13170 (2669728) 2669728..2670375 - 648 WP_001187630.1 HD domain-containing protein -
NRK31_RS13175 (2670403) 2670403..2671887 - 1485 WP_000571549.1 cardiolipin synthase -
NRK31_RS13180 (2672053) 2672053..2672346 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NRK31_RS13185 (2672358) 2672358..2672567 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NRK31_RS13190 (2672695) 2672695..2672832 + 138 WP_000828354.1 Lmo0850 family protein -
NRK31_RS13195 (2673096) 2673096..2674298 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NRK31_RS13200 (2674616) 2674616..2675686 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NRK31_RS13205 (2675701) 2675701..2677059 + 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T279177 WP_000581792.1 NZ_CP123852:2672358-2672567 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT279177 WP_000138932.1 NZ_CP123852:2672053-2672346 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References