Detailed information of TA system TA027917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/AbrB(antitoxin)
• Location: 2473876..2474516
• Replicon: chromosome
• Accession: NC_018020
• Organism: Turneriella parva DSM 21527

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: I4B6X2
• Locus tag: TURPA_RS11815
• Protein ID: WP_014803535.1
• Coordinates: 2474157..2474516 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: I4B6X1
• Locus tag: TURPA_RS11810
• Protein ID: WP_014803534.1
• Coordinates: 2473876..2474094 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TURPA_RS23440	2470384..2470542	+	159	WP_157210477.1	hypothetical protein	-
TURPA_RS11795	2470841..2471380	+	540	WP_014803531.1	hypothetical protein	-
TURPA_RS21870	2471570..2473270	+	1701	WP_014803532.1	InlB B-repeat-containing protein	-
TURPA_RS11805	2473406..2473768	-	363	WP_014803533.1	cysteine rich repeat-containing protein	-
TURPA_RS11810	2473876..2474094	+	219	WP_014803534.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TURPA_RS11815	2474157..2474516	+	360	WP_014803535.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
TURPA_RS11820	2474509..2475717	+	1209	WP_014803536.1	GTPase ObgE	-
TURPA_RS11825	2475745..2476188	-	444	WP_014803537.1	hypothetical protein	-
TURPA_RS11830	2476185..2477015	-	831	WP_014803538.1	hypothetical protein	-
TURPA_RS11835	2477038..2478060	-	1023	WP_014803539.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-113)

Antitoxin

• SpoVT-AbrB domain (4-42)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13148.46 Da
• Isoelectric Point: 10.7058

>T27917 WP_014803535.1 NC_018020:2474157-2474516 [Turneriella parva DSM 21527]
MNHLVQFDVVKVPFPFTELPFMKRRPAVVLSDAAAFQFSAGEGKRVLAMITSSKHKPWPLDTHLSSLKDAGLSQDSLIRL
KIFTLDESLILAKIGALSRKDRATLSANLAKLFALEKNA

Nucleotide

• Length: 360 bp

>T27917 NC_018020:2474157-2474516 [Turneriella parva DSM 21527]
ATGAATCATCTCGTGCAATTCGACGTCGTCAAGGTGCCATTTCCCTTTACGGAGCTGCCTTTCATGAAGCGAAGGCCAGC
GGTTGTCCTTTCTGATGCTGCGGCATTTCAGTTTTCTGCGGGCGAGGGCAAACGCGTGCTCGCCATGATCACAAGCAGCA
AACACAAGCCCTGGCCGCTCGATACCCATCTGAGTTCTCTCAAAGACGCAGGGCTCAGTCAAGATTCGCTGATTCGACTC
AAGATTTTCACGCTCGATGAATCATTGATTCTTGCAAAGATTGGCGCCCTGTCTCGAAAAGACAGAGCAACCTTAAGCGC
GAATCTCGCAAAGCTTTTCGCCCTGGAAAAAAATGCATAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8223.30 Da
• Isoelectric Point: 4.7558

>AT27917 WP_014803534.1 NC_018020:2473876-2474094 [Turneriella parva DSM 21527]
MSAVTAKYQATLPKPVREKLQLKAGDKVTFSIENDRVYIQKATGFDVPYLRSLETTLEEWASPEDEEAYKNL

Nucleotide

• Length: 219 bp

>AT27917 NC_018020:2473876-2474094 [Turneriella parva DSM 21527]
ATGAGTGCTGTTACAGCCAAATATCAAGCCACTTTGCCTAAGCCTGTGCGTGAGAAGCTGCAGCTTAAGGCGGGTGACAA
AGTCACATTCTCAATAGAAAACGATCGGGTGTACATCCAGAAAGCGACCGGCTTCGATGTACCCTATTTGCGCTCGCTCG
AAACGACGCTTGAAGAGTGGGCGTCGCCTGAAGACGAAGAGGCTTATAAAAATCTATAG

Structures

Toxin

• AlphaFold DB: I4B6X2

Antitoxin

• AlphaFold DB: I4B6X1