Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 361329..362119 Replicon plasmid pAtH25_79a
Accession NZ_CP123849
Organism Agrobacterium fabacearum strain H25/79

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1S7NFF1
Locus tag G6L82_RS24670 Protein ID WP_019565755.1
Coordinates 361622..362119 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1S7NER6
Locus tag G6L82_RS24665 Protein ID WP_019565754.1
Coordinates 361329..361625 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L82_RS24645 (G6L82_024645) 356697..358421 + 1725 WP_019565751.1 ABC transporter ATP-binding protein -
G6L82_RS24650 (G6L82_024650) 358466..359653 + 1188 WP_145166916.1 galactarate dehydratase -
G6L82_RS24655 (G6L82_024655) 359640..360506 + 867 WP_145166983.1 aldose 1-epimerase -
G6L82_RS24660 (G6L82_024660) 360716..361146 + 431 Protein_368 DDE-type integrase/transposase/recombinase -
G6L82_RS24665 (G6L82_024665) 361329..361625 + 297 WP_019565754.1 DUF1778 domain-containing protein Antitoxin
G6L82_RS24670 (G6L82_024670) 361622..362119 + 498 WP_019565755.1 GNAT family N-acetyltransferase Toxin
G6L82_RS24675 (G6L82_024675) 362738..363286 + 549 WP_019565757.1 TRAP transporter small permease subunit -
G6L82_RS24680 (G6L82_024680) 363304..364809 + 1506 WP_173995354.1 TRAP transporter large permease subunit -
G6L82_RS24685 (G6L82_024685) 364873..365985 + 1113 WP_065703185.1 TRAP transporter substrate-binding protein -
G6L82_RS24690 (G6L82_024690) 366049..366681 - 633 WP_173995355.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..628949 628949


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-142)

Antitoxin

Vibrio phage ICP1, Orf50

(16-90)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17725.27 Da        Isoelectric Point: 6.8629

>T279167 WP_019565755.1 NZ_CP123849:361622-362119 [Agrobacterium fabacearum]
VTLSAPVPLADHHELAEFNSGVPELDDWLRRRARANQAGGASRTFVVCDESRVIAYYALASGSVKPPEVPGRFRRNMPDP
IPVAVLGRLAIDQSCQGRGIGRALVRDAGLRLLNAAEVLGIRGVLVHAISDDARAFYEAVGFLSSPSDPMMLMVGLHDLN
NALNT

Download         Length: 498 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11022.59 Da        Isoelectric Point: 7.0159

>AT279167 WP_019565754.1 NZ_CP123849:361329-361625 [Agrobacterium fabacearum]
MPTSHTGKSPDASVPLNMRIKPATRNLIDRAAELLGKTRTDFMLEASERRAEEVLLDRTIVTVSPEIYAEYLARLDAPAQ
PNERLKRTMSTKAPWDEA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7NFF1

Antitoxin

Source ID Structure
AlphaFold DB A0A1S7NER6

References