Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 6697..8207 Replicon chromosome
Accession NZ_CP123848
Organism Agrobacterium fabacearum strain H25/79

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag G6L82_RS13555 Protein ID WP_173995344.1
Coordinates 6697..7938 (-) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag G6L82_RS13560 Protein ID WP_111790926.1
Coordinates 7935..8207 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L82_RS13520 (G6L82_013520) 2028..2237 - 210 WP_139104336.1 hypothetical protein -
G6L82_RS13525 (G6L82_013525) 2409..2531 - 123 Protein_4 plasmid maintenance toxin (PemK-like) -
G6L82_RS13530 (G6L82_013530) 2518..2790 - 273 WP_029658823.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
G6L82_RS13535 (G6L82_013535) 3403..3528 - 126 WP_255610345.1 hypothetical protein -
G6L82_RS13540 (G6L82_013540) 3795..4088 + 294 WP_173996183.1 hypothetical protein -
G6L82_RS13545 (G6L82_013545) 4162..5256 - 1095 WP_173995346.1 LuxR C-terminal-related transcriptional regulator -
G6L82_RS13550 (G6L82_013550) 6567..6707 - 141 WP_173995345.1 hypothetical protein -
G6L82_RS13555 (G6L82_013555) 6697..7938 - 1242 WP_173995344.1 type II toxin-antitoxin system HipA family toxin Toxin
G6L82_RS13560 (G6L82_013560) 7935..8207 - 273 WP_111790926.1 helix-turn-helix domain-containing protein Antitoxin
G6L82_RS13565 (G6L82_013565) 8629..8949 + 321 WP_173995343.1 hypothetical protein -
G6L82_RS13570 (G6L82_013570) 9073..9201 + 129 WP_003518932.1 hypothetical protein -
G6L82_RS13575 (G6L82_013575) 9314..9883 + 570 WP_112154996.1 AAA family ATPase -
G6L82_RS13580 (G6L82_013580) 9861..10481 + 621 WP_173995342.1 histidine phosphatase family protein -
G6L82_RS13585 (G6L82_013585) 10552..10935 + 384 WP_173995341.1 ester cyclase -
G6L82_RS13590 (G6L82_013590) 11142..11801 + 660 WP_111796711.1 porin family protein -
G6L82_RS13595 (G6L82_013595) 12466..12681 + 216 WP_065659437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 45346.22 Da        Isoelectric Point: 7.9060

>T279162 WP_173995344.1 NZ_CP123848:c7938-6697 [Agrobacterium fabacearum]
MTTIYYETLPVAHLTFEGEWRLDYDPGWEARRPAFPVSLTMPLRSGSVGAAKLLPWLANLLPETHLAEIGQRFKVSPQDI
VGLLAHIGRDTAGALSIGEPRKAGVNLRPVPDEQALERILNELPAKPFLVGERGVSMSLAGVQEKLPVFVDGNGRISVPV
DGTPSTHILKPDTKRLAGSVENEAFCLSLARACGLEAAEVTIGVAGKRRYLLVKRCDRFTDAQGEIRRLHQEDLCQLTGY
FPSQKYERSSTGGGVTMKMMFDAVSDLVSPGERLKLLDAVIFNVLICNSDSHAKNYSILIGAGGSAKMAPLYDLMCAAVY
RQVDQSLPQGISGRFHAPDLRRADWQALADDIGLSGASTLKRVEELAKLVSVACEEVAPHIVALSRHPTRILERITHSVQ
KRCRRIQEQMHDR

Download         Length: 1242 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9655.05 Da        Isoelectric Point: 6.2834

>AT279162 WP_111790926.1 NZ_CP123848:c8207-7935 [Agrobacterium fabacearum]
MFRSARDFGAAIKERRKALGWTQTGLAARSGTGERFIVELESGKPSCQLEKALIVARAVGIDLGDLKTVQAVQVASDDDL
GFLPMFGADQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References