Detailed information of TA system TA027915

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 2058531..2059096
• Replicon: chromosome
• Accession: NC_018020
• Organism: Turneriella parva DSM 21527

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: I4B9N0
• Locus tag: TURPA_RS09945
• Protein ID: WP_014803172.1
• Coordinates: 2058531..2058854 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: I4B5V9
• Locus tag: TURPA_RS09950
• Protein ID: WP_014803173.1
• Coordinates: 2058848..2059096 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TURPA_RS23415	2054591..2055277	+	687	WP_014803167.1	AraC family transcriptional regulator	-
TURPA_RS09925	2055159..2055749	+	591	WP_157210461.1	hemerythrin domain-containing protein	-
TURPA_RS09930	2055789..2056184	+	396	WP_014803169.1	hypothetical protein	-
TURPA_RS09935	2056230..2057024	+	795	WP_014803170.1	hypothetical protein	-
TURPA_RS09940	2057376..2058203	+	828	WP_041948444.1	hypothetical protein	-
TURPA_RS09945	2058531..2058854	-	324	WP_014803172.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
TURPA_RS09950	2058848..2059096	-	249	WP_014803173.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TURPA_RS09955	2059452..2059994	+	543	WP_014803174.1	GNAT family N-acetyltransferase	-
TURPA_RS09965	2060304..2061062	+	759	WP_157210462.1	hypothetical protein	-
TURPA_RS09970	2061400..2062014	+	615	WP_157210463.1	immunity 63 family protein	-
TURPA_RS09975	2062149..2062781	+	633	WP_014803178.1	M23 family metallopeptidase	-
TURPA_RS09980	2063179..2063808	+	630	WP_014803179.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12084.41 Da
• Isoelectric Point: 10.3758

>T27915 WP_014803172.1 NC_018020:c2058854-2058531 [Turneriella parva DSM 21527]
MVVEQYDVFLINLDPTIGHEIKKTRPCLIISPNEMNGNISTIIIAPMTTVSRNYPTRVKTVFKKKTGYIVLDQIRTVDKA
RLVKKLGKVNIEAIGSVKSVLREMLID

Nucleotide

• Length: 324 bp

>T27915 NC_018020:c2058854-2058531 [Turneriella parva DSM 21527]
ATGGTAGTGGAACAATACGACGTATTTCTGATAAATCTTGATCCGACTATCGGCCATGAGATTAAGAAAACCAGGCCCTG
CCTTATCATATCACCAAATGAGATGAATGGTAATATTTCTACGATAATCATCGCCCCTATGACAACTGTTTCGCGAAATT
ATCCGACACGAGTGAAAACAGTATTCAAGAAGAAGACCGGATATATAGTCCTCGACCAGATTCGTACGGTCGATAAAGCG
CGTTTAGTTAAGAAGCTTGGTAAGGTCAATATTGAAGCCATTGGCTCAGTTAAGTCAGTTTTGCGAGAAATGCTTATAGA
TTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9471.97 Da
• Isoelectric Point: 9.6894

>AT27915 WP_014803173.1 NC_018020:c2059096-2058848 [Turneriella parva DSM 21527]
MILQIVKVGNSKGLRIPKSILEQYHIEDEVDVTSTKDGLLLKPIKSKARAGWAKKFKEMATNRDDRLLMPDFTDAADRDW
QW

Nucleotide

• Length: 249 bp

>AT27915 NC_018020:c2059096-2058848 [Turneriella parva DSM 21527]
ATGATCTTGCAGATAGTAAAGGTGGGCAACTCGAAAGGGCTGCGTATCCCCAAAAGTATTTTGGAACAATACCATATCGA
AGATGAGGTGGATGTCACTTCGACGAAAGATGGACTTCTCTTGAAACCGATTAAAAGTAAGGCTCGAGCAGGTTGGGCAA
AGAAATTCAAAGAGATGGCGACAAACCGGGATGATAGATTATTAATGCCCGATTTCACAGATGCGGCAGATCGAGACTGG
CAATGGTAG

Structures

Toxin

• AlphaFold DB: I4B9N0

Antitoxin

• AlphaFold DB: I4B5V9