279147

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1546520..1547147 Replicon chromosome
Accession NZ_CP123771
Organism Pseudomonas viciae strain YsS1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QCD61_RS06960 Protein ID WP_256452322.1
Coordinates 1546932..1547147 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QCD61_RS06955 Protein ID WP_280944754.1
Coordinates 1546520..1546930 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCD61_RS06925 (QCD61_06925) 1541917..1542333 + 417 WP_135844141.1 fosfomycin resistance glutathione transferase -
QCD61_RS06930 (QCD61_06930) 1542522..1543871 + 1350 WP_135844142.1 diguanylate cyclase -
QCD61_RS06935 (QCD61_06935) 1544153..1544656 + 504 WP_135844143.1 DUF4142 domain-containing protein -
QCD61_RS06940 (QCD61_06940) 1544733..1545641 + 909 WP_135844144.1 SDR family oxidoreductase -
QCD61_RS06945 (QCD61_06945) 1545690..1546094 - 405 WP_135844145.1 low affinity iron permease family protein -
QCD61_RS06950 (QCD61_06950) 1546268..1546414 + 147 WP_178084240.1 hypothetical protein -
QCD61_RS06955 (QCD61_06955) 1546520..1546930 - 411 WP_280944754.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QCD61_RS06960 (QCD61_06960) 1546932..1547147 - 216 WP_256452322.1 type II toxin-antitoxin system HicA family toxin Toxin
QCD61_RS06965 (QCD61_06965) 1547435..1548064 - 630 WP_256452323.1 LysE family translocator -
QCD61_RS06970 (QCD61_06970) 1548210..1548689 + 480 WP_135844149.1 Lrp/AsnC family transcriptional regulator -
QCD61_RS06975 (QCD61_06975) 1548713..1549267 - 555 WP_265072791.1 hypothetical protein -
QCD61_RS06980 (QCD61_06980) 1549737..1549991 + 255 WP_280944755.1 type II toxin-antitoxin system HicA family toxin -
QCD61_RS06985 (QCD61_06985) 1549988..1550320 + 333 WP_024616089.1 type II toxin-antitoxin system HicB family antitoxin -
QCD61_RS06995 (QCD61_06995) 1550828..1551712 - 885 WP_256452325.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 7713.89 Da        Isoelectric Point: 10.2823

>T279147 WP_256452322.1 NZ_CP123771:c1547147-1546932 [Pseudomonas viciae]
VNSRFLISQIIADGGYLVRGRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALLQTASCATSAEDD

Download         Length: 216 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14750.79 Da        Isoelectric Point: 4.7168

>AT279147 WP_280944754.1 NZ_CP123771:c1546930-1546520 [Pseudomonas viciae]
MLYPIAISMGDDKHAWGVEVPDIPGCFSAGDDLDEAMAMAREAIEGHFEILADDGSPIPSANTVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQGR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References