Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1667..2195 Replicon plasmid pAP8900-4
Accession NZ_CP123769
Organism Acinetobacter pittii strain AP8900

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag QFB56_RS20245 Protein ID WP_000221358.1
Coordinates 1902..2195 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag QFB56_RS20240 Protein ID WP_000246755.1
Coordinates 1667..1912 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB56_RS20225 (QFB56_20225) 536..727 + 192 WP_000102616.1 hypothetical protein -
QFB56_RS20230 (QFB56_20230) 770..1168 - 399 WP_024437500.1 hypothetical protein -
QFB56_RS20235 (QFB56_20235) 1190..1525 - 336 WP_159452829.1 hypothetical protein -
QFB56_RS20240 (QFB56_20240) 1667..1912 + 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QFB56_RS20245 (QFB56_20245) 1902..2195 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB56_RS20250 (QFB56_20250) 2423..2740 + 318 WP_005065053.1 hypothetical protein -
QFB56_RS20255 (QFB56_20255) 3224..3496 - 273 WP_094069338.1 NadS family protein -
QFB56_RS20260 (QFB56_20260) 3489..3809 - 321 WP_199953181.1 type II toxin-antitoxin system RelE/ParE family toxin -
QFB56_RS20265 (QFB56_20265) 3968..4747 + 780 WP_199953180.1 pentapeptide repeat-containing protein -
QFB56_RS20270 (QFB56_20270) 4934..5794 + 861 WP_199953179.1 restriction endonuclease -
QFB56_RS20275 (QFB56_20275) 5911..6522 - 612 WP_199953178.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11346 11346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T279143 WP_000221358.1 NZ_CP123769:1902-2195 [Acinetobacter pittii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT279143 WP_000246755.1 NZ_CP123769:1667-1912 [Acinetobacter pittii]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References