279141

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 40166..40754 Replicon plasmid pAP8900-2
Accession NZ_CP123767
Organism Acinetobacter pittii strain AP8900

Toxin (Protein)


Gene name brnT Uniprot ID N8SM64
Locus tag QFB56_RS20095 Protein ID WP_000438825.1
Coordinates 40166..40453 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID D3JXQ4
Locus tag QFB56_RS20100 Protein ID WP_004728120.1
Coordinates 40440..40754 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB56_RS20075 (QFB56_20075) 35882..36496 - 615 WP_081318675.1 hypothetical protein -
QFB56_RS20080 (QFB56_20080) 36605..37084 - 480 WP_139118978.1 hypothetical protein -
QFB56_RS20085 (QFB56_20085) 37397..39352 - 1956 WP_000693745.1 alkyl sulfatase dimerization domain-containing protein -
QFB56_RS20090 (QFB56_20090) 39416..39613 - 198 Protein_39 IS30 family transposase -
QFB56_RS20095 (QFB56_20095) 40166..40453 + 288 WP_000438825.1 BrnT family toxin Toxin
QFB56_RS20100 (QFB56_20100) 40440..40754 + 315 WP_004728120.1 BrnA antitoxin family protein Antitoxin
QFB56_RS20105 (QFB56_20105) 40843..41373 - 531 WP_000172759.1 hypothetical protein -
QFB56_RS20110 (QFB56_20110) 41522..41824 + 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
QFB56_RS20115 (QFB56_20115) 41825..42106 + 282 WP_000985609.1 putative addiction module antidote protein -
QFB56_RS20120 (QFB56_20120) 42186..42605 - 420 WP_001180106.1 SMI1/KNR4 family protein -
QFB56_RS20125 (QFB56_20125) 42745..43065 + 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin -
QFB56_RS20130 (QFB56_20130) 43058..43330 + 273 WP_000369781.1 NadS family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(E) / mph(E) / tet(39) / cmlB1 / sul2 / aph(3'')-Ib / aph(6)-Id - 1..43600 43600
- flank IS/Tn - - 39416..39610 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11304.70 Da        Isoelectric Point: 5.6205

>T279141 WP_000438825.1 NZ_CP123767:40166-40453 [Acinetobacter pittii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12200.86 Da        Isoelectric Point: 8.4628

>AT279141 WP_004728120.1 NZ_CP123767:40440-40754 [Acinetobacter pittii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TVQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8TRI9

References