Detailed information of TA system TA027914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1467156..1467787
• Replicon: chromosome
• Accession: NC_018020
• Organism: Turneriella parva DSM 21527

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: TURPA_RS07140
• Protein ID: WP_041948376.1
• Coordinates: 1467386..1467787 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: I4B4A0
• Locus tag: TURPA_RS07135
• Protein ID: WP_014802621.1
• Coordinates: 1467156..1467389 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TURPA_RS07110	1463794..1464087	+	294	WP_014802616.1	antibiotic biosynthesis monooxygenase	-
TURPA_RS07115	1464087..1464302	+	216	WP_014802617.1	membrane protein insertion efficiency factor YidD	-
TURPA_RS07120	1464304..1465401	-	1098	WP_014802618.1	DUF418 domain-containing protein	-
TURPA_RS07125	1465401..1466642	-	1242	WP_014802619.1	MFS transporter	-
TURPA_RS07130	1466722..1467114	+	393	WP_014802620.1	VOC family protein	-
TURPA_RS07135	1467156..1467389	+	234	WP_014802621.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TURPA_RS07140	1467386..1467787	+	402	WP_041948376.1	PIN domain-containing protein	Toxin
TURPA_RS07145	1467778..1468596	+	819	WP_157210430.1	alpha/beta hydrolase	-
TURPA_RS07150	1468597..1469460	+	864	WP_014802624.1	RluA family pseudouridine synthase	-
TURPA_RS07155	1469461..1469790	-	330	WP_014802625.1	toxin-antitoxin system HicB family antitoxin	-
TURPA_RS07160	1469787..1469990	-	204	WP_014802626.1	type II toxin-antitoxin system HicA family toxin	-
TURPA_RS07165	1470095..1470370	-	276	WP_014802627.1	hypothetical protein	-
TURPA_RS07170	1470477..1470785	+	309	WP_014802628.1	nucleotidyltransferase domain-containing protein	-
TURPA_RS07175	1470778..1471122	+	345	WP_014802629.1	DUF86 domain-containing protein	-
TURPA_RS07180	1471169..1471978	-	810	Protein_1426	hypothetical protein	-
TURPA_RS07185	1472231..1472446	+	216	WP_014802631.1	hypothetical protein	-
TURPA_RS07190	1472439..1472705	+	267	WP_157210626.1	type II toxin-antitoxin system YafQ family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-125)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14981.43 Da
• Isoelectric Point: 8.8343

>T27914 WP_041948376.1 NC_018020:1467386-1467787 [Turneriella parva DSM 21527]
MMYLLDTNICIYTIKQRSTTFIDKFKAAKLQGRVGISAITYAELQYGIQKSQRRSENQVALAQFLVPLKTFEFDEKAGIL
FGEIKTALEKMGTPIGSYDMLIAAHALSLDATLITNNEGEFRRVPGLKVENWL

Nucleotide

• Length: 402 bp

>T27914 NC_018020:1467386-1467787 [Turneriella parva DSM 21527]
CTGATGTATTTGCTCGACACGAATATCTGCATCTACACTATCAAGCAACGCTCAACCACATTCATCGACAAATTCAAAGC
AGCGAAGCTACAAGGTCGCGTTGGCATTTCGGCGATCACCTACGCTGAACTTCAATATGGCATTCAAAAAAGCCAGCGCC
GCAGCGAAAATCAGGTGGCTCTCGCGCAATTTTTGGTACCGCTCAAGACATTCGAATTTGACGAAAAGGCGGGCATACTC
TTTGGCGAAATCAAAACTGCGCTCGAAAAAATGGGTACACCGATAGGCTCTTATGACATGCTGATCGCGGCGCATGCGTT
GTCGCTCGATGCGACGCTCATCACGAACAACGAGGGCGAATTTCGGCGAGTACCAGGGCTAAAGGTAGAGAATTGGCTGT
AA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8848.08 Da
• Isoelectric Point: 8.5285

>AT27914 WP_014802621.1 NC_018020:1467156-1467389 [Turneriella parva DSM 21527]
MNTAKLFKNGESQAVRLPKEYRFKGSEVYITKHSNVVMLIPKSKNTWDIMKEAVGEFSEDIFAEGRQQPEEQVRSGL

Nucleotide

• Length: 234 bp

>AT27914 NC_018020:1467156-1467389 [Turneriella parva DSM 21527]
ATGAACACGGCAAAACTCTTCAAGAACGGCGAAAGTCAGGCTGTGCGCCTACCAAAAGAATATCGCTTCAAGGGTAGCGA
AGTCTATATTACGAAACACTCGAACGTGGTGATGCTGATACCAAAGTCGAAAAACACATGGGATATCATGAAAGAGGCAG
TCGGCGAATTCAGTGAAGATATCTTTGCCGAAGGCAGGCAGCAACCTGAAGAGCAGGTGCGTTCAGGTCTCTGA

Structures

Antitoxin

• AlphaFold DB: I4B4A0