279138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3166..3750 Replicon plasmid pAP8900-1
Accession NZ_CP123766
Organism Acinetobacter pittii strain AP8900

Toxin (Protein)


Gene name PumA Uniprot ID N9JY46
Locus tag QFB56_RS19340 Protein ID WP_000286963.1
Coordinates 3448..3750 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag QFB56_RS19335 Protein ID WP_000985610.1
Coordinates 3166..3447 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB56_RS19310 (QFB56_19310) 288..506 + 219 WP_029747731.1 hypothetical protein -
QFB56_RS19315 (QFB56_19315) 616..825 - 210 WP_000069471.1 hypothetical protein -
QFB56_RS19320 (QFB56_19320) 818..1120 - 303 WP_001140619.1 XRE family transcriptional regulator -
QFB56_RS19325 (QFB56_19325) 1113..1469 - 357 WP_006581604.1 type II toxin-antitoxin system RelE/ParE family toxin -
QFB56_RS19330 (QFB56_19330) 2090..2962 - 873 WP_006581603.1 restriction endonuclease -
QFB56_RS19335 (QFB56_19335) 3166..3447 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
QFB56_RS19340 (QFB56_19340) 3448..3750 - 303 WP_000286963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB56_RS19345 (QFB56_19345) 3942..4334 + 393 WP_228713465.1 hypothetical protein -
QFB56_RS19350 (QFB56_19350) 4346..5278 - 933 WP_002048759.1 IS5 family transposase -
QFB56_RS19355 (QFB56_19355) 5332..5811 + 480 Protein_9 GIY-YIG nuclease family protein -
QFB56_RS19360 (QFB56_19360) 5913..7003 + 1091 WP_085940648.1 IS4-like element ISAba1 family transposase -
QFB56_RS19365 (QFB56_19365) 7200..7562 - 363 Protein_11 plasmid replication DNA-binding protein -
QFB56_RS19370 (QFB56_19370) 7596..7820 - 225 WP_125510319.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 - 1..86394 86394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11545.02 Da        Isoelectric Point: 4.6838

>T279138 WP_000286963.1 NZ_CP123766:c3750-3448 [Acinetobacter pittii]
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT279138 WP_000985610.1 NZ_CP123766:c3447-3166 [Acinetobacter pittii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836MGN2

Antitoxin

Source ID Structure

References