Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1827214..1827748 Replicon chromosome
Accession NZ_CP123735
Organism Lactobacillus kefiranofaciens strain ZW18

Toxin (Protein)


Gene name Txe Uniprot ID -
Locus tag QEJ78_RS09200 Protein ID WP_013854792.1
Coordinates 1827214..1827477 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A656YAM3
Locus tag QEJ78_RS09205 Protein ID WP_013854791.1
Coordinates 1827461..1827748 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEJ78_RS09180 (QEJ78_09190) 1822410..1823931 + 1522 Protein_1774 L-lactate permease -
QEJ78_RS09185 (QEJ78_09195) 1824105..1824266 + 162 WP_013854794.1 hypothetical protein -
QEJ78_RS09190 (QEJ78_09200) 1824966..1825574 + 609 WP_013851264.1 IS607 family transposase -
QEJ78_RS09195 (QEJ78_09205) 1825604..1826929 + 1326 WP_013851263.1 RNA-guided endonuclease TnpB family protein -
QEJ78_RS09200 (QEJ78_09210) 1827214..1827477 - 264 WP_013854792.1 Txe/YoeB family addiction module toxin Toxin
QEJ78_RS09205 (QEJ78_09215) 1827461..1827748 - 288 WP_013854791.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QEJ78_RS09210 (QEJ78_09220) 1827878..1828354 - 477 WP_013854790.1 S-ribosylhomocysteine lyase -
QEJ78_RS09215 (QEJ78_09225) 1828417..1829517 - 1101 WP_013854789.1 vitamin B12 independent methionine synthase -
QEJ78_RS09220 (QEJ78_09230) 1830214..1830690 + 477 WP_013854787.1 hypothetical protein -
QEJ78_RS09225 (QEJ78_09235) 1830687..1830884 + 198 WP_013854786.1 helix-turn-helix transcriptional regulator -
QEJ78_RS09230 (QEJ78_09240) 1830859..1831092 + 234 WP_025084256.1 bacteriocin immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1704570..1837618 133048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10486.95 Da        Isoelectric Point: 9.3821

>T279130 WP_013854792.1 NZ_CP123735:c1827477-1827214 [Lactobacillus kefiranofaciens]
MLSWTDDGCDDYLNWQKQRQKKKIKRINKLITDIKRHPFEGMGKPEGLKNNLTGLWSRKIDAKNRIIYEYTNENVIIYSC
KDHYDDH

Download         Length: 264 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10874.12 Da        Isoelectric Point: 4.5296

>AT279130 WP_013854791.1 NZ_CP123735:c1827748-1827461 [Lactobacillus kefiranofaciens]
MDAVNYSNFRKDLKTYFKQVNDDSEPLIVTNKNPEDNVVVLSKDEYDALIETLAIQSNKYLMDKINRGRKQVAKAQTNQH
ELIDPDGEVSDAKLD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A656YAM3

References