Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1293032..1293657 Replicon chromosome
Accession NC_018017
Organism Desulfitobacterium dehalogenans ATCC 51507

Toxin (Protein)


Gene name pemK Uniprot ID Q24Q87
Locus tag DESDE_RS06250 Protein ID WP_005817423.1
Coordinates 1293307..1293657 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I4A6X7
Locus tag DESDE_RS06245 Protein ID WP_014793202.1
Coordinates 1293032..1293310 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DESDE_RS06225 1288672..1289202 - 531 WP_014793198.1 gamma carbonic anhydrase family protein -
DESDE_RS06230 1289481..1290497 + 1017 WP_014793199.1 2-hydroxyacid dehydrogenase family protein -
DESDE_RS06235 1290634..1292034 + 1401 WP_014793200.1 DUF1727 domain-containing protein -
DESDE_RS06240 1292038..1292802 + 765 WP_014793201.1 glutamine amidotransferase -
DESDE_RS06245 1293032..1293310 + 279 WP_014793202.1 ribbon-helix-helix protein, CopG family Antitoxin
DESDE_RS06250 1293307..1293657 + 351 WP_005817423.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DESDE_RS06255 1293943..1294736 + 794 Protein_1228 MBL fold metallo-hydrolase -
DESDE_RS06260 1295134..1295859 + 726 WP_014793203.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
DESDE_RS06265 1296238..1298472 - 2235 WP_014793204.1 sigma-54-dependent Fis family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-39)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12824.86 Da        Isoelectric Point: 5.8944

>T27913 WP_005817423.1 NC_018017:1293307-1293657 [Desulfitobacterium dehalogenans ATCC 51507]
MIIKRGEIYYAELNPVVGSEQGGTRPVLVIQNDIGNQFSPTTIIAAITSQIAKAKLPTHVEVRAKRSGLERDSVILTEQI
RTIDKSRLKEKVAVLDEEVMLRVDQAIEISLGLTDI

Download         Length: 351 bp

>T27913 NC_018017:1293307-1293657 [Desulfitobacterium dehalogenans ATCC 51507]
ATGATCATAAAACGCGGGGAAATCTACTATGCTGAACTCAACCCCGTCGTCGGATCCGAGCAAGGCGGTACCCGTCCTGT
GTTGGTGATCCAAAATGATATCGGAAATCAGTTTAGTCCGACGACTATTATTGCTGCGATTACATCTCAGATTGCAAAAG
CAAAGTTGCCGACTCATGTGGAGGTGCGGGCAAAACGTAGTGGTTTAGAACGGGATTCGGTCATTTTGACTGAACAGATT
CGAACGATTGACAAAAGCCGCCTCAAGGAGAAGGTCGCCGTTCTTGATGAAGAAGTAATGTTGAGAGTGGATCAAGCGAT
CGAAATCAGCTTGGGGCTGACTGATATTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10862.33 Da        Isoelectric Point: 4.6550

>AT27913 WP_014793202.1 NC_018017:1293032-1293310 [Desulfitobacterium dehalogenans ATCC 51507]
VAESKRIMISLPENLLAEVDDVVTLENRNRSEFIREAINSVLHERRKRGIREQMRKGYEEMAQLNLAIARELFLTEEEVQ
LVYEDSNVECQR

Download         Length: 279 bp

>AT27913 NC_018017:1293032-1293310 [Desulfitobacterium dehalogenans ATCC 51507]
GTGGCAGAAAGTAAGCGGATAATGATTAGTTTGCCGGAGAATTTGCTCGCGGAAGTGGATGATGTCGTTACGCTAGAAAA
TAGAAATCGTAGCGAATTTATACGTGAAGCAATAAACAGTGTTCTTCATGAACGCCGGAAACGGGGAATCCGCGAGCAAA
TGCGTAAAGGTTATGAGGAAATGGCTCAATTGAACTTAGCCATTGCCAGAGAGCTGTTCCTCACAGAGGAAGAGGTCCAA
TTGGTTTATGAAGATTCTAATGTGGAGTGTCAGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M7T493

Antitoxin

Source ID Structure
AlphaFold DB I4A6X7

References