Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelE-RHH |
Location | 98724..99271 | Replicon | plasmid pN38232-1 |
Accession | NZ_CP123661 | ||
Organism | Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G7QEJ9 |
Locus tag | DE22_RS23435 | Protein ID | WP_001384452.1 |
Coordinates | 98993..99271 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | E1QMW3 |
Locus tag | DE22_RS23430 | Protein ID | WP_000079941.1 |
Coordinates | 98724..98993 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DE22_RS23400 (94430) | 94430..95233 | + | 804 | WP_001082319.1 | aminoglycoside O-phosphotransferase APH(3'')-Ib | - |
DE22_RS23405 (95233) | 95233..96069 | + | 837 | WP_000480968.1 | aminoglycoside O-phosphotransferase APH(6)-Id | - |
DE22_RS23410 (96391) | 96391..96645 | + | 255 | WP_000083830.1 | replication regulatory protein RepA | - |
DE22_RS23415 (96684) | 96684..96920 | - | 237 | WP_223228793.1 | replication protein RepA | - |
DE22_RS23420 (96911) | 96911..96958 | + | 48 | WP_077822033.1 | hypothetical protein | - |
DE22_RS23425 (96951) | 96951..97808 | + | 858 | WP_000130940.1 | incFII family plasmid replication initiator RepA | - |
DE22_RS23430 (98724) | 98724..98993 | + | 270 | WP_000079941.1 | type II toxin-antitoxin system antitoxin YacA | Antitoxin |
DE22_RS23435 (98993) | 98993..99271 | + | 279 | WP_001384452.1 | type II toxin-antitoxin system toxin YacB | Toxin |
DE22_RS23440 (99317) | 99317..100165 | + | 849 | WP_001057989.1 | 3'-5' exonuclease | - |
DE22_RS23445 (100351) | 100351..102231 | + | 1881 | WP_001283335.1 | colicin Ia central receptor-binding domain-containing protein | - |
DE22_RS23450 (102253) | 102253..102588 | - | 336 | WP_001080729.1 | colicin 1A immunity protein | - |
DE22_RS23455 (102835) | 102835..103239 | + | 405 | WP_000839181.1 | transposase | - |
DE22_RS23460 (103236) | 103236..103583 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | sitABCD / tet(B) / aph(3'')-Ib / aph(6)-Id | iucA / iucB / iucC / iucD / iutA / iroN / iroE / iroD / iroC / iroB | 1..146005 | 146005 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10762.38 Da Isoelectric Point: 8.4615
>T279128 WP_001384452.1 NZ_CP123661:98993-99271 [Salmonella enterica subsp. enterica serovar Kentucky]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP
Download Length: 279 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CL36 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A629TXC5 |