Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4288517..4289298 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3V9S3T1
Locus tag DE22_RS20685 Protein ID WP_000625910.1
Coordinates 4288517..4289008 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag DE22_RS20690 Protein ID WP_001110453.1
Coordinates 4289005..4289298 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS20660 (4283653) 4283653..4286091 - 2439 WP_001014137.1 F4 (K88) fimbrial usher FaeD -
DE22_RS20665 (4286101) 4286101..4286640 - 540 WP_000721295.1 type 1 fimbrial protein -
DE22_RS20670 (4286675) 4286675..4286965 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
DE22_RS20675 (4287552) 4287552..4287809 + 258 WP_001112993.1 hypothetical protein -
DE22_RS20680 (4288054) 4288054..4288302 - 249 Protein_4043 IS481 family transposase -
DE22_RS20685 (4288517) 4288517..4289008 - 492 WP_000625910.1 GNAT family N-acetyltransferase Toxin
DE22_RS20690 (4289005) 4289005..4289298 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
DE22_RS20695 (4289616) 4289616..4289837 + 222 WP_031617221.1 hypothetical protein -
DE22_RS20700 (4290101) 4290101..4290976 + 876 WP_000921674.1 AraC family transcriptional regulator -
DE22_RS20705 (4290973) 4290973..4291260 + 288 WP_001269916.1 transcriptional regulator RtsB -
DE22_RS20710 (4291253) 4291253..4291435 - 183 WP_024133183.1 ATP-binding cassette domain-containing protein -
DE22_RS20715 (4291473) 4291473..4291553 + 81 Protein_4050 hypothetical protein -
DE22_RS20720 (4291663) 4291663..4291797 + 135 Protein_4051 hypothetical protein -
DE22_RS20725 (4292092) 4292092..4292997 - 906 WP_001268257.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4277030..4291579 14549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.51 Da        Isoelectric Point: 7.7297

>T279125 WP_000625910.1 NZ_CP123660:c4289008-4288517 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQITGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT279125 WP_001110453.1 NZ_CP123660:c4289298-4289005 [Salmonella enterica subsp. enterica serovar Kentucky]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9S3T1

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References