279124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4173184..4173827 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag DE22_RS20065 Protein ID WP_000048134.1
Coordinates 4173411..4173827 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag DE22_RS20060 Protein ID WP_001261294.1
Coordinates 4173184..4173414 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS20050 (4170198) 4170198..4172336 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DE22_RS20055 (4172553) 4172553..4173017 + 465 WP_001009176.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DE22_RS20060 (4173184) 4173184..4173414 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DE22_RS20065 (4173411) 4173411..4173827 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
DE22_RS20070 (4173888) 4173888..4175801 - 1914 WP_001212141.1 BglG family transcription antiterminator -
DE22_RS20075 (4175818) 4175818..4176558 - 741 WP_000779262.1 KDGP aldolase family protein -
DE22_RS20080 (4176555) 4176555..4177673 - 1119 WP_001139172.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DE22_RS20085 (4177657) 4177657..4178790 - 1134 WP_000459943.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T279124 WP_000048134.1 NZ_CP123660:4173411-4173827 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT279124 WP_001261294.1 NZ_CP123660:4173184-4173414 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References