Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4083578..4084154 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag DE22_RS19670 Protein ID WP_001131963.1
Coordinates 4083867..4084154 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag DE22_RS19665 Protein ID WP_000063143.1
Coordinates 4083578..4083880 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS19650 (4080125) 4080125..4082275 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
DE22_RS19655 (4082333) 4082333..4082536 + 204 WP_000460616.1 YbdD/YjiX family protein -
DE22_RS19660 (4082547) 4082547..4083503 + 957 WP_000187838.1 GTPase -
DE22_RS19665 (4083578) 4083578..4083880 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
DE22_RS19670 (4083867) 4083867..4084154 - 288 WP_001131963.1 BrnT family toxin Toxin
DE22_RS19675 (4084423) 4084423..4085337 - 915 WP_000290512.1 restriction endonuclease -
DE22_RS19680 (4085535) 4085535..4089044 + 3510 WP_001043486.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T279123 WP_001131963.1 NZ_CP123660:c4084154-4083867 [Salmonella enterica subsp. enterica serovar Kentucky]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT279123 WP_000063143.1 NZ_CP123660:c4083880-4083578 [Salmonella enterica subsp. enterica serovar Kentucky]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References