Detailed information of TA system TA027912

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1509133..1509647
• Replicon: chromosome
• Accession: NC_018016
• Organism: Ornithobacterium rhinotracheale DSM 15997

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I4A110
• Locus tag: ORNRH_RS07105
• Protein ID: WP_014791206.1
• Coordinates: 1509390..1509647 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I4A109
• Locus tag: ORNRH_RS07100
• Protein ID: WP_014791205.1
• Coordinates: 1509133..1509387 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ORNRH_RS07085	1504329..1505456	+	1128	WP_014791202.1	imelysin family protein	-
ORNRH_RS07090	1505483..1506850	+	1368	WP_014791203.1	HTTM domain-containing protein	-
ORNRH_RS07095	1506831..1509062	+	2232	WP_014791204.1	TonB-dependent receptor	-
ORNRH_RS07100	1509133..1509387	+	255	WP_014791205.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
ORNRH_RS07105	1509390..1509647	+	258	WP_014791206.1	Txe/YoeB family addiction module toxin	Toxin
ORNRH_RS07110	1509703..1509996	-	294	WP_014791207.1	chaperone modulator CbpM	-
ORNRH_RS07115	1510002..1510928	-	927	WP_014791208.1	J domain-containing protein	-
ORNRH_RS07120	1510980..1511753	-	774	WP_014791209.1	nucleoside triphosphate pyrophosphohydrolase	-
ORNRH_RS07125	1511842..1512267	-	426	WP_014791210.1	DUF5606 domain-containing protein	-
ORNRH_RS07130	1512317..1512889	-	573	WP_014791211.1	peptide deformylase	-
ORNRH_RS07135	1513040..1513453	-	414	WP_155814511.1	Holliday junction resolvase RuvX	-
ORNRH_RS12175	1513468..1513761	-	294	WP_014791213.1	ATP-dependent Clp protease adaptor ClpS	-
ORNRH_RS07145	1513765..1514595	-	831	WP_036601380.1	50S ribosomal protein L11 methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10592.16 Da
• Isoelectric Point: 8.4443

>T27912 WP_014791206.1 NC_018016:1509390-1509647 [Ornithobacterium rhinotracheale DSM 15997]
MKYIFVDESWEDYLYWQKDDKRKLKRINALLKDISRTPFEGIGKPEPLKHKYSGFWSRRIDDEHCLIYRYEEDKILIAKC
RFHYD

Nucleotide

• Length: 258 bp

>T27912 NC_018016:1509390-1509647 [Ornithobacterium rhinotracheale DSM 15997]
ATGAAATATATTTTTGTAGATGAATCTTGGGAAGATTATCTATATTGGCAAAAAGACGATAAACGAAAGCTTAAAAGAAT
CAATGCTTTGTTGAAAGATATTTCGCGCACGCCTTTTGAAGGTATTGGCAAACCTGAGCCATTAAAACATAAATATTCAG
GATTTTGGTCACGCAGAATTGATGATGAACATTGTTTAATTTACCGTTACGAAGAAGATAAAATCCTGATTGCCAAATGT
AGATTTCATTATGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9587.97 Da
• Isoelectric Point: 6.3475

>AT27912 WP_014791205.1 NC_018016:1509133-1509387 [Ornithobacterium rhinotracheale DSM 15997]
MLVTNISEFRKDLKSYLNKVAKNFETLIINRGKESAIVVLSLDEYNSLMATNYELSSRKNEQRLDAAIAKLKSGESFEKT
LIED

Nucleotide

• Length: 255 bp

>AT27912 NC_018016:1509133-1509387 [Ornithobacterium rhinotracheale DSM 15997]
ATGCTAGTTACCAATATTTCAGAATTTAGAAAAGATTTAAAATCCTATTTAAACAAGGTTGCAAAAAACTTTGAAACCTT
AATCATTAATCGTGGAAAAGAATCTGCAATCGTGGTTTTGTCGCTTGATGAGTATAATTCTTTGATGGCGACAAATTATG
AACTGTCTTCTCGCAAAAACGAACAGCGTCTAGATGCTGCAATAGCAAAATTGAAATCAGGAGAATCATTTGAGAAAACA
CTGATTGAAGATTAA

Structures

Toxin

• AlphaFold DB: I4A110

Antitoxin

• AlphaFold DB: I4A109