279118

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3460476..3461096 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DE22_RS16765 Protein ID WP_001280991.1
Coordinates 3460878..3461096 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DE22_RS16760 Protein ID WP_000344807.1
Coordinates 3460476..3460850 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS16750 (3455615) 3455615..3456808 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DE22_RS16755 (3456831) 3456831..3459980 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DE22_RS16760 (3460476) 3460476..3460850 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DE22_RS16765 (3460878) 3460878..3461096 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DE22_RS16770 (3461275) 3461275..3461826 + 552 WP_001278788.1 maltose O-acetyltransferase -
DE22_RS16775 (3461942) 3461942..3462412 + 471 WP_000136183.1 YlaC family protein -
DE22_RS16780 (3462468) 3462468..3462608 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DE22_RS16785 (3462614) 3462614..3462874 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DE22_RS16790 (3463099) 3463099..3464649 + 1551 WP_000213144.1 EAL domain-containing protein -
DE22_RS16800 (3464880) 3464880..3465269 + 390 WP_000961285.1 MGMT family protein -
DE22_RS16805 (3465302) 3465302..3465871 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T279118 WP_001280991.1 NZ_CP123660:3460878-3461096 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT279118 WP_000344807.1 NZ_CP123660:3460476-3460850 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References