279117

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2437925..2438447 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag DE22_RS11775 Protein ID WP_000221345.1
Coordinates 2438163..2438447 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DE22_RS11770 Protein ID WP_000885424.1
Coordinates 2437925..2438173 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS11735 (2433107) 2433107..2433442 + 336 WP_001519747.1 hypothetical protein -
DE22_RS11740 (2433752) 2433752..2434015 + 264 WP_129589477.1 hypothetical protein -
DE22_RS11745 (2434279) 2434279..2435208 + 930 WP_001518895.1 hypothetical protein -
DE22_RS11750 (2435547) 2435547..2435879 - 333 WP_000253156.1 DUF1493 family protein -
DE22_RS11755 (2436295) 2436295..2436402 - 108 Protein_2297 IS110 family transposase -
DE22_RS11760 (2436767) 2436767..2437156 + 390 WP_001044696.1 hypothetical protein -
DE22_RS11765 (2437159) 2437159..2437512 + 354 WP_000418733.1 hypothetical protein -
DE22_RS11770 (2437925) 2437925..2438173 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DE22_RS11775 (2438163) 2438163..2438447 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DE22_RS11780 (2438618) 2438618..2439007 + 390 WP_000194089.1 RidA family protein -
DE22_RS11785 (2439065) 2439065..2440138 - 1074 WP_000954681.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DE22_RS11790 (2440331) 2440331..2440819 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
DE22_RS11795 (2440864) 2440864..2442372 + 1509 WP_000199403.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2425625..2445229 19604


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T279117 WP_000221345.1 NZ_CP123660:2438163-2438447 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT279117 WP_000885424.1 NZ_CP123660:2437925-2438173 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References