279112

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1166562..1167229 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name ypjF Uniprot ID A0A3V9RYJ5
Locus tag DE22_RS05630 Protein ID WP_023139840.1
Coordinates 1166562..1166891 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A3V9RY53
Locus tag DE22_RS05635 Protein ID WP_000065828.1
Coordinates 1166912..1167229 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS05610 (1163074) 1163074..1163646 - 573 WP_000190912.1 flagellar phase variation DNA invertase Hin -
DE22_RS05615 (1163738) 1163738..1165240 + 1503 WP_000079789.1 FliC/FljB family flagellin -
DE22_RS05620 (1165308) 1165308..1165847 + 540 WP_000388869.1 phase 1 flagellin gene repressor FljA -
DE22_RS05625 (1165875) 1165875..1166097 + 223 Protein_1099 helix-turn-helix domain-containing protein -
DE22_RS05630 (1166562) 1166562..1166891 - 330 WP_023139840.1 TA system toxin CbtA family protein Toxin
DE22_RS05635 (1166912) 1166912..1167229 - 318 WP_000065828.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DE22_RS05640 (1167248) 1167248..1167469 - 222 WP_000691990.1 DUF987 domain-containing protein -
DE22_RS05645 (1167478) 1167478..1167960 - 483 WP_001518223.1 DNA repair protein RadC -
DE22_RS05650 (1167969) 1167969..1168427 - 459 WP_000155322.1 antirestriction protein -
DE22_RS05655 (1168513) 1168513..1168731 - 219 WP_031225670.1 DUF905 domain-containing protein -
DE22_RS05660 (1168738) 1168738..1168971 - 234 Protein_1106 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1166562..1180170 13608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12271.23 Da        Isoelectric Point: 9.4828

>T279112 WP_023139840.1 NZ_CP123660:c1166891-1166562 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTLPATISRATKPCLSPVAVWQMLLTRLLDQHYGLTLNDTPFSDKTVIQEYINAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQSPYLSVVDILQARRSTGLLKTDVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11913.44 Da        Isoelectric Point: 6.6246

>AT279112 WP_000065828.1 NZ_CP123660:c1167229-1166912 [Salmonella enterica subsp. enterica serovar Kentucky]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECRRLDETFPHFISQMESMLTTGEMNPRHAHCVILYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9RYJ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9RY53

References