Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1030491..1031305 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3V9S344
Locus tag DE22_RS04940 Protein ID WP_000971652.1
Coordinates 1030491..1031018 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag DE22_RS04945 Protein ID WP_000855694.1
Coordinates 1031015..1031305 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS04910 (1026694) 1026694..1027092 + 399 Protein_961 cytoplasmic protein -
DE22_RS04915 (1027303) 1027303..1027521 + 219 Protein_962 hypothetical protein -
DE22_RS04920 (1027678) 1027678..1028346 + 669 WP_000445911.1 hypothetical protein -
DE22_RS04925 (1028373) 1028373..1028867 + 495 WP_000424941.1 hypothetical protein -
DE22_RS04930 (1029112) 1029112..1029768 - 657 WP_000420454.1 protein-serine/threonine phosphatase -
DE22_RS04935 (1029995) 1029995..1030418 + 424 Protein_966 transposase -
DE22_RS04940 (1030491) 1030491..1031018 - 528 WP_000971652.1 GNAT family N-acetyltransferase Toxin
DE22_RS04945 (1031015) 1031015..1031305 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
DE22_RS04950 (1031899) 1031899..1032225 + 327 WP_000393298.1 hypothetical protein -
DE22_RS04955 (1032497) 1032497..1032844 - 348 WP_001555786.1 DUF1493 family protein -
DE22_RS04960 (1032829) 1032829..1033278 - 450 WP_000381618.1 hypothetical protein -
DE22_RS04965 (1033710) 1033710..1034153 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
DE22_RS04970 (1034610) 1034610..1035260 + 651 WP_023166786.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1029112..1040573 11461
- flank IS/Tn - - 1030278..1030418 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19041.94 Da        Isoelectric Point: 9.8881

>T279111 WP_000971652.1 NZ_CP123660:c1031018-1030491 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLKDQPLSLLL
SFKTLYAALAASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT279111 WP_000855694.1 NZ_CP123660:c1031305-1031015 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9S344

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References