Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 865361..866021 Replicon chromosome
Accession NZ_CP123660
Organism Salmonella enterica subsp. enterica serovar Kentucky strain CVM N38232

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag DE22_RS04185 Protein ID WP_000244756.1
Coordinates 865608..866021 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DE22_RS04180 Protein ID WP_000351186.1
Coordinates 865361..865627 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DE22_RS04160 (861290) 861290..862723 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
DE22_RS04165 (862881) 862881..863192 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DE22_RS04170 (863356) 863356..864015 + 660 WP_000250285.1 hemolysin III family protein -
DE22_RS04175 (864131) 864131..865111 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
DE22_RS04180 (865361) 865361..865627 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DE22_RS04185 (865608) 865608..866021 + 414 WP_000244756.1 protein YgfX Toxin
DE22_RS04190 (866074) 866074..866595 - 522 WP_001055885.1 flavodoxin FldB -
DE22_RS04195 (866708) 866708..867604 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DE22_RS04200 (867628) 867628..868341 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DE22_RS04205 (868347) 868347..870080 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T279110 WP_000244756.1 NZ_CP123660:865608-866021 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT279110 WP_000351186.1 NZ_CP123660:865361-865627 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References